171543-83-2

Basic information

• Product Name: UROCORTIN (RAT)
• Synonyms: Urocortin ratUrocortin;Urocortin (sheep);Urocortin(Rattus norvegicus) (9CI);UROCORTIN (RAT);UROCORTIN (RAT) (FREE ACID);UROCORTIN (RAT) (MOUSE);H-ASP-ASP-PRO-PRO-LEU-SER-ILE-ASP-LEU-THR-PHE-HIS-LEU-LEU-ARG-THR-LEU-LEU-GLU-LEU-ALA-ARG-THR-GLN-SER-GLN-ARG-GLU-ARG-ALA-GLU-GLN-ASN-ARG-ILE-ILE-PHE-ASP-SER-VAL-NH2;H-ASP-ASP-PRO-PRO-LEU-SER-ILE-ASP-LEU-THR-PHE-HIS-LEU-LEU-ARG-THR-LEU-LEU-GLU-LEU-ALA-ARG-THR-GLN-SER-GLN-ARG-GLU-ARG-ALA-GLU-GLN-ASN-ARG-ILE-ILE-PHE-ASP-SER-VAL-OH
• CAS NO: 171543-83-2
• Molecular Formula: C206H338N62O64
• Molecular Weight: 4707.26492
• Product Categories: Peptide;CRFPeptides for Cell Biology;CRF;Neuropeptides;Releasing Factors;CRF receptor and related
• Mol File: 171543-83-2.mol
• Article Data: 0

Chemical Properties

• Appearance: /powder
• Storage Temp.: −20°C
• Solubility: 1% acetic acid: >1 mg/mL, clear, colorless
• CAS DataBase Reference: UROCORTIN (RAT)(CAS DataBase Reference)
• NIST Chemistry Reference: UROCORTIN (RAT)(171543-83-2)
• EPA Substance Registry System: UROCORTIN (RAT)(171543-83-2)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 171543-83-2(Hazardous Substances Data)

Usage

Uses

Urocortin rat can be used for western blotting. The product can also be used for studying that whether CRF receptor type 2 (CRF2) and its high-affinity ligand, urocortin 1 (Ucn1) can mediate sex-specific cellular stress responses by using corticotropin-releasing factor receptor 2-deficient (Crhr2-/- ) and wild-type (WT) mice.

Biochem/physiol Actions

Urocortin is a CRF-related neuropeptide that binds to CRF receptor types 1α, 2α and 2β. It possesses appetite-suppressing effect. Urocortin along with corticotropin-releasing factor (CRF) binding protein (CRF-BP) enhances the free CRF levels in human brain by displacing hCRF from the binding protein.