171550-12-2

Basic information

• Product Name: 4-(4-Hydrazinobenzyl)-2-oxazolidinone
• Synonyms: (S)-4-(4'-AMINOBENZYL)-1,3-OXAZOLIDIN-2-ONE;(S)-4-(4-AMINOBENZYL)-1,3-OXAZOLIDIN-2-ONE;(S)-4-(4'-AMINOBENZYL)-2-OXAZOLIDINONE;(S)-4-(4-AMINOBENZYL)-2-OXAZOLIDINONE;(S)-4-(4-AMINO-BENZYL)-OXAZOLIDIN-2-ONE;(S)-4-(4-AMINO-BENZYL)-OXAZOLIDINE-2-ONE;4-(4-hydrazinobenzyl)-2-oxazolidinone;4-[(4-hydrazinophenyl)methyl]-2-oxazolidinone
• CAS NO: 171550-12-2
• Molecular Formula: C10H13N3O2
• Molecular Weight: 207.23
• Product Categories: (intermediate of zolmitriptan]
• Mol File: 171550-12-2.mol

Chemical Properties

• Melting Point: 107-111 °C
• Boiling Point: 519°C
• Flash Point: 267.891°C
• Appearance: /
• Density: 1.318
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.639
• PKA: 12.65±0.40(Predicted)
• Water Solubility: 0.58 g/L (25 ºC)
• CAS DataBase Reference: 4-(4-Hydrazinobenzyl)-2-oxazolidinone(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-Hydrazinobenzyl)-2-oxazolidinone(171550-12-2)
• EPA Substance Registry System: 4-(4-Hydrazinobenzyl)-2-oxazolidinone(171550-12-2)

Safety Data

• Hazard Codes: Xn
• Statements: 22-36/37/38
• Safety Statements: 26-36/37
• WGK Germany: 2
• Hazardous Substances Data: 171550-12-2(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Research:
4-(4-Hydrazinobenzyl)-2-oxazolidinone is used as a novel antibiotic for its antimicrobial properties, offering a new avenue for combating resistant bacteria.
Used in Antitumor Applications:
In the field of oncology, 4-(4-Hydrazinobenzyl)-2-oxazolidinone is used as an antitumor agent for its ability to inhibit the growth of tumor cells, showing promise in the treatment of various cancers.
Used in Anti-inflammatory Applications:
4-(4-Hydrazinobenzyl)-2-oxazolidinone is utilized as an anti-inflammatory agent due to its capacity to reduce inflammation, which is beneficial in managing a range of inflammatory conditions.
Used in Antioxidant Applications:
4-(4-Hydrazinobenzyl)-2-oxazolidinone is employed as an antioxidant in pharmaceutical formulations to protect against oxidative stress and related diseases, contributing to overall health and wellness.
Used in Cancer Treatment:
4-(4-Hydrazinobenzyl)-2-oxazolidinone is used in cancer treatment research for its potential to target and inhibit the proliferation of cancer cells, offering a new therapeutic strategy in oncology.
Used in Drug Development:
In the development of new drugs, 4-(4-Hydrazinobenzyl)-2-oxazolidinone is used as an ingredient for its multifunctional properties, which can be leveraged to create medications for a variety of medical conditions.

InChI:InChI=1/C10H13N3O2/c11-13-8-3-1-7(2-4-8)5-9-6-15-10(14)12-9/h1-4,9,13H,5-6,11H2,(H,12,14)

Upstream product

• 152305-23-2 (S)-4-(4-aminobenzyl)-1,3-oxazolidin-2-one 

Downstream Products

• 139264-57-6 (S)-4-(4-hydrazinobenzyl)-1,3-oxazolidin-2-one hydrochloride 

Relevant articles and documents

Convenient and industrially viable process for preparation of zolmitriptan

The present invention provides a convenient and industrially viable process for preparation of zolmitriptan. The invention specifically relates to a method for obtaining (S)-4-(4-hydrazinobenzyl)-1,3-oxazolidin-2-one hydrochloride of desired purity by separation and isolation in a particular pH range to give higher yield and purity.

PROCESS FOR PREPARATION OF ZOLMITRIPTAN

The present invention provides a convenient and industrially viable process for preparation of Zolmitriptan (I) having desired purity. The invention specifically relates to a method for isolating (S)-4-(4-hydrazinobenzyl)-1,3-oxazolidin-2-one hydrochloride (IIIa) of desired purity by separating the undesired inorganic side products such as stannous hydroxide by manipulation of pH at different stages and finally treating with N,N-dimethylamino butyraldehyde diethyl acetal in an acidic medium to provide Zolmitriptan (I) conforming to regulatory specifications.

PROCESS FOR THE PREPARATION OF ZOLMITRIPTAN, SALTS AND SOLVATES THEREOF

The present invention relates to an improved process for the preparation of the active pharmaceutical ingredient zolmitriptan. In particular, it relates to an efficient process for the preparation of zolmitriptan and its pharmaceutically acceptable salts and solvates.

PROCESS FOR THE PREPARATION OF ZOLMITRIPTAN, SALTS AND SOLVATES THEREOF

The present invention relates to an improved process for the preparation of the activepharmaceutical ingredient zolmitriptan. In particular, it relates to an efficient process for the preparation of zolmitriptan and its pharmaceutically acceptable salts and solvates.

N-Desmethyltriptans: One pot efficient synthesis of N-methyl-2-5- [substituted- 1H- indole-3-yl]ethanamines

A straightforward and highly improved method to synthesize N-methyl-2-[5-[substituted-lH-indole-3-yl]ethanamines 4-6, which are the metabolites of tryptans 1-3, is reported. The significance of the process is its simplicity and efficiency in isolating the N- desmethyltriptans derivatives as a free base.

CONVERSION OF AROMATIC DIAZONIUM SALT TO ARYL HYDRAZINE

The present invention relates to the preparation of aryl hydrazines and their salts by treating aryl diazonium salts with triphenyl phosphine followed by hydrolysis of the resulting triphenyl-aryl hydrazyl phosphonium salt to get aryl hydrazine or its sal