17156-65-9 Usage
Description
(METHYLDIPHENYLSILYL)ACETYLENE, also known as diphenylmethylethynylsilane, is an organic building block with various physical properties such as boiling point and density. It is a compound that consists of a silicon atom bonded to a phenyl group, a methyl group, and an acetylene group, which contributes to its unique chemical properties and potential applications.
Uses
Used in Chemical Synthesis:
(METHYLDIPHENYLSILYL)ACETYLENE is used as a synthetic building block for the creation of diphenylmethylsilyl-substituted isoxazoles. This is achieved through a [2+3] cycloaddition reaction with nitrile oxides, which allows for the formation of complex molecular structures with potential applications in various fields.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, (METHYLDIPHENYLSILYL)ACETYLENE may be utilized as a key intermediate in the synthesis of novel drug candidates. Its unique structure can be exploited to design and develop new molecules with specific biological activities, potentially leading to the discovery of new therapeutic agents.
Used in Materials Science:
(METHYLDIPHENYLSILYL)ACETYLENE could also be employed in the field of materials science, where its properties can be harnessed to create new materials with tailored characteristics. For instance, its incorporation into polymers or other materials could lead to improved mechanical, thermal, or electrical properties, depending on the desired application.
Check Digit Verification of cas no
The CAS Registry Mumber 17156-65-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,7,1,5 and 6 respectively; the second part has 2 digits, 6 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 17156-65:
(7*1)+(6*7)+(5*1)+(4*5)+(3*6)+(2*6)+(1*5)=109
109 % 10 = 9
So 17156-65-9 is a valid CAS Registry Number.
InChI:InChI=1/C15H14Si/c1-3-16(2,14-10-6-4-7-11-14)15-12-8-5-9-13-15/h1,4-13H,2H3
17156-65-9Relevant articles and documents
Three-coordinate copper(II) alkynyl complex in C-C bond formation: The sesquicentennial of the glaser coupling
Warren, Timothy H.,Bakhoda, Abolghasem,Okoromoba, Otome E.,Greene, Christine,Boroujeni, Mahdi Raghibi,Bertke, Jeffery A.
supporting information, p. 18483 - 18490 (2020/11/27)
Copper(II) alkynyl species are proposed as key intermediates in numerous Cu-catalyzed C-C coupling reactions. Supported by a β-diketiminate ligand, the three-coordinate copper(II) alkynyl [CuII]-C≡CAr (Ar = 2,6-Cl2C6H3) forms upon reaction of the alkyne H-C≡CAr with the copper(II) tertbutoxide complex [CuII]-OtBu. In solution, this [CuII]-C≡CAr species cleanly transforms to the Glaser coupling product ArC≡C-C≡CAr and [CuI](solvent). Addition of nucleophiles R′C≡C-Li (R′ = aryl, silyl) and Ph-Li to [CuII]-C≡CAr affords the corresponding Csp-Csp and Csp-Csp2 coupled products RC≡C-C≡CAr and Ph-C≡CAr with concomitant generation of [CuI](solvent) and {[CuI]-C≡CAr}-, respectively. Supported by density functional theory (DFT) calculations, redox disproportionation forms [CuIII](C≡CAr)(R) species that reductively eliminate R-C≡CAr products. [CuII]-C≡CAr also captures the trityl radical Ph3C· to give Ph3C-C≡CAr. Radical capture represents the key Csp-Csp3 bond-forming step in the copper-catalyzed C-H functionalization of benzylic substrates R-H with alkynes H-C≡CR′ (R′ = (hetero)aryl, silyl) that provide Csp-Csp3 coupled products R-C≡CR via radical relay with tBuOOtBu as oxidant.
SILICON-DIRECTED NAZAROV CYCLIZATIONS - IV FURTHER STUDIES IN STEREOCHEMICAL CONTROL
Denmark, Scott E.,Habermas, Karl L.,Hite, Gary A.,Jones, Todd K.
, p. 2821 - 2829 (2007/10/02)
The silicon-directed Nazarov cyclization was shown to proceed with good to excellent stereoselectivity in cyclohexenyl systems bearing a variety of ring substituents.In all cases the trans family of isomers predominated, and cis ring-fused products were f
