171561-41-4Relevant academic research and scientific papers
Synthesis of 5-Phosphonyl-2(1H)-pyridones from Primary β-Enaminophosphonate and Acetylenic Esters
Palacios, Francisco,Garcia, Jesus,Retana, Ana M Ochoa,Oyarzabal, Julen
, p. 1915 - 1922 (2007/10/02)
Primary β-enaminophosphonates (2) are obtained from metallated diethyl methylphosphonate and nitriles.Reaction of enamines (2) with ethyl propiolate and dimethyl acetylenedicarboxylate yields 1:1 adducts (7) and (8), respectively.Treatment of monoadducts (7) with sodium hydride leads to 5-phosphonyl-2(1H)-pyridones (1).Functionalized enamines (8) undergo thermal cyclocondensation to give pyridones (9).
