171565-87-0

Basic information

• Product Name: (R-Biar)-7,8-dibenzyloxy-4,13-dihydro-6,9,10,11-tetramethoxydibenzo<4,5:6,7>cycloocta<1,2-c>furan-1(3H)-one
• Synonyms: (R-Biar)-7,8-dibenzyloxy-4,13-dihydro-6,9,10,11-tetramethoxydibenzo<4,5:6,7>cycloocta<1,2-c>furan-1(3H)-one
• CAS NO: 171565-87-0
• Molecular Weight: 594.661
• Mol File: 171565-87-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (R-Biar)-7,8-dibenzyloxy-4,13-dihydro-6,9,10,11-tetramethoxydibenzo<4,5:6,7>cycloocta<1,2-c>furan-1(3H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: (R-Biar)-7,8-dibenzyloxy-4,13-dihydro-6,9,10,11-tetramethoxydibenzo<4,5:6,7>cycloocta<1,2-c>furan-1(3H)-one(171565-87-0)
• EPA Substance Registry System: (R-Biar)-7,8-dibenzyloxy-4,13-dihydro-6,9,10,11-tetramethoxydibenzo<4,5:6,7>cycloocta<1,2-c>furan-1(3H)-one(171565-87-0)

Safety Data

• Hazardous Substances Data: 171565-87-0(Hazardous Substances Data)

Upstream product

• 146120-72-1 (S)-(E)-2-(3,4,5-trimethoxybenzylidene)-3-<3-methoxy-4,5-bis(4-nitrobenzyloxy)benzyl>-butanolide 
• 146236-45-5 (S)-(E)-3-<5-Methoxy-3,4-(methylenedioxy)benzyl>-2-(3,4,5-trimethoxybenzylidene)butanolide 
• 146236-44-4 (S)-(E)-3-(3,4-Dihydroxy-5-methoxybenzyl)-2-(3,4,5-trimethoxybenzylidene)butanolide 
• 143616-16-4 (S)-3-methoxycarbonyl-4-<5-methoxy-3,4-(methylenedioxy)phenyl>butanoic acid 
• 143616-17-5 (S)-(E)-3-<5-Methoxy-3,4-(methylenedioxy)benzyl>butanolide 
• 78173-83-8 (E)-3-methoxycarbonyl-4-<5-methoxy-3,4-(methylenedioxy)phenyl>but-3-enoic acid 

Relevant articles and documents

Total Syntheses of the Metabolites of Schizandrin

The total syntheses of the metabolites of schizandrin were achieved.The tetracyclic lactone intermediates (13a-e) were prepared in optically pure form by the oxidative coupling reaction of the corresponding 3-benzyl-2-benzylidenebutyrolactones.Mukaiyama hydration of 13b afforded hydroxylactone (14), which was converted into SZ-M3 (4).The introduction of C6,7-diol moiety, which is common to the metabolites (4-11), was carried out by the successive double bond migration to 15a-e, lactone ring reduction ot the allylic diols (32a-e), and glycol formation.Then, reduction of the mesylates 33 completed the syntheses of the metabolites.