17159-42-1Relevant articles and documents
In situ 1H NMR study of cytochrome P450 inhibition by metyrapol in mycobacterium aurum MO1
Combourieu,Besse,Sancelme,Veschambre,Delort
, p. 1624 - 1628 (2007/10/03)
In situ 1H NMR was used to monitor incubations of Mycobacterium aurum MO1 with thiomorpholine or morpholine in the presence of metyrapone, a specific inhibitor of P450. Unexpected signals were detected and assigned to metyrapol, the reduction product of metyrapone. The inhibitory effects of racemic metyrapol and of its (-)-enantiomer were compared to that of metyrapone. They are similar.
Reduction of drug ketones by dihydrodiol dehydrogenases, carbonyl reductase and aldehyde reductase of human liver
Ohara, Hirotami,Miyabe, Yoshiyuki,Deyashiki, Yoshihiro,Matsuura, Kazuya,Hara, Akira
, p. 221 - 227 (2007/10/03)
In this study, we compared the enzymatic reduction of 10 drugs with a ketone group by homogeneous carbonyl reductase, aldehyde reductase and three dihydrodiol dehydrogenases of human liver cytosol. At least one and in some cases all of the three dihydrodi