17159-87-4Relevant academic research and scientific papers
COMPOUNDS FOR THE TREATMENT OF HIV
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, (2013/03/26)
The invention provides compounds of formula (I): or a salt thereof as described herein. The invention also provides pharmaceutical compositions comprising a compound of formula (I), processes for preparing compounds of formula (I), intermediates useful for preparing compounds of formula I and therapeutic methods for treating a Retroviridae viral infection including an infection caused by the HIV virus.
A New Synthesis of Bicycloocta-2,4-diene and Its Cycloaddition Reactions with Dienophiles.
Yin, Tyze-Kuan,Lee, Jon Gun,Borden, Weston Thatcher
, p. 531 - 534 (2007/10/02)
Bicycloocta-2,4-diene (4) has been synthesized by a new, nine-step route, starting from 2--1,3-butadiene and acrolein.Diene (4) proved almost as unreactive toward Diels-Alder cycloadditions as the previously studied 7,7-dimethy
SYNTHESIS OF THROMBOXANE A2 ANALOGS-1. (+/-)-DIMETHANOTHROMBOXANE A2
Ohuchida, Shuichi,Hamanaka, Nobuyuki,Hayashi, Masaki
, p. 4257 - 4262 (2007/10/02)
The stable thromboxane A2 analog (+/-)-dimethanothromboxane A2 1 was synthesized from bicycloheptane 2 via the tricyclic compound 4.
Regioselectivity in Ring-Expansion of 1-Substituted Bicyclohexan-2-ones: Preferential Migration of Methylene Over Bridgehead Carbon
Della, Ernest W.,Pigou, Paul E.
, p. 2261 - 2268 (2007/10/02)
Ring expansion of several 1-substituted bicyclohexan-2-ones has been investigated in order to compare the effect od substitution on the migratory aptitude of the bridgehead carbon in relation to the methylene carbon.In the cases examined it was observed that there is a marked preference for migration of the methylene carbon, with the substituted substrates displaying higher regioselectivity that the parent ketone.In the rearrangement of both 1-fluoro- and 1-chloro-bicyclohexan-2-one, migration of the methylene carbon occurs exclusively.
A FACILE SYNTHESIS OF 2-FORMYLBICYCLOHEPT-2-ENE
Cooper, G. F.,VanHorn, A. R.,Wren, D.
, p. 1213 - 1218 (2007/10/02)
A short synthesis of 2-formylbicyclohept-2-ene, suitable for multigram preparations, is presented.
Deamination Reactions. 35. Decomposition of 5-Norbornene-2-diazonium Ions. Derivatives of Bicyclohept-2-ene
Kirmse, Wolfgang,Knoepfel, Norbert,Loosen, Karin,Siegfried, Rainer,Wroblowsky, Heinz-Juergen
, p. 1187 - 1191 (2007/10/02)
Photolysis of 5-norbornen-2-one tosylhydrazone (4) in aqueous sodium hydroxide afforded 4percent of 3-norpinen-2-ol (3) in addition to 5-norbornen-2-ol (5, 10percent) and nortricyclanol (6, 86percent). 3 arises from 5-norbornene-2endo-diazonium ions (2) as shown by the nitrous acid deamination of the epimeric amines 1 and 7. 3-Norpinen-2-one (12) was isolated by oxidation of the deamination products followed by preparative g.l.c. 3 and 12 were synthesized independently from norpinan-2-one (9) via sulfenylation and sulfoxide pyrolysis.The norbornene -> norpinene rearrangement is slightly enhanced by 1-OCH3.The deamination of 1-methoxy-5-norbornen-2endo-amine (14) produced 10percent of 12, as compared to 5.6percent of 3 from 1.
Carbocyclic thromboxane A2 analogues
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, (2008/06/13)
Stable biologically active thromboxane A2 analogues having the formula: STR1 wherein R1 is OR3, where R3 represents hydrogen or a pharmaceutically acceptable cation or lower alkyl group; or R1 is NR4 R5 where R4 and R5 are the same or different substituents selected from the group consisting of hydrogen and lower alkyl group; and R2 is hydrogen or an --OH group. The thromboxane analogues are potent thrombotic agents, useful in cardiovascular treatment.
