171598-74-6

Basic information

• Product Name: trans (2,3)-Dihydro Tetrabenazine
• Synonyms: trans (2,3)-Dihydro Tetrabenazine;(2R,3R,11bR)-rel-1,3,4,6,7,11b-Hexahydro-9,10-diMethoxy-3-(2-Methylpropyl)-2H-benzo[a]quinolizin-2-ol;NBI-98854
• CAS NO: 171598-74-6
• Molecular Formula: C19H29NO3
• Molecular Weight: 319.43846
• Product Categories: Chiral Reagents;Heterocycles;Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals
• Mol File: 171598-74-6.mol
• Article Data: 0

Chemical Properties

• Melting Point: 167-170°C
• Boiling Point: 457.8±45.0 °C(Predicted)
• Appearance: /
• Density: 1.13±0.1 g/cm3(Predicted)
• Storage Temp.: Refrigerator
• Solubility: Dichloromethane (Slightly), DMSO (Slightly, Heated) Methanol (Slightly)
• PKA: 14.75±0.40(Predicted)
• CAS DataBase Reference: trans (2,3)-Dihydro Tetrabenazine(CAS DataBase Reference)
• NIST Chemistry Reference: trans (2,3)-Dihydro Tetrabenazine(171598-74-6)
• EPA Substance Registry System: trans (2,3)-Dihydro Tetrabenazine(171598-74-6)

Safety Data

• Hazardous Substances Data: 171598-74-6(Hazardous Substances Data)

Usage

Description

Trans (2,3)-Dihydro Tetrabenazine, a metabolite of Tetrabenazine in vivo, is a white solid with significant pharmaceutical applications. It is primarily known for its role in treating hyperkinetic movement disorders, which are characterized by excessive and involuntary muscle movements.

Uses

Used in Pharmaceutical Industry:
Trans (2,3)-Dihydro Tetrabenazine is used as a therapeutic agent for the treatment of hyperkinetic movement disorders. It helps in managing the symptoms by targeting the excess dopamine in the brain, which is responsible for the uncontrollable muscle movements.
Used in Neurology:
In the field of neurology, trans (2,3)-Dihydro Tetrabenazine is used as a medication to alleviate the severity of hyperkinetic movement disorders. It is particularly beneficial for patients suffering from conditions like Huntington's disease, where the symptoms include chorea (involuntary, rapid, and irregular movements) and dystonia (muscle contractions resulting in twisting and repetitive movements or fixed postures).
Used in Research and Development:
Trans (2,3)-Dihydro Tetrabenazine is also utilized in research and development for understanding the underlying mechanisms of hyperkinetic movement disorders and exploring potential new treatment options. Its study contributes to the advancement of knowledge in the field of neuroscience and pharmacology.