171611-77-1Relevant articles and documents
Synthesis of a new potent anti-angiogenic agent, 17α-acetoxy-9α- fluoro-6α-methylprogesterone (9α-fluoromedroxyprogesterone acetate [FMPA])
Sugino, Eiichi,Fujimori, Shiho,Hibino, Satoshi,Choshi, Tominari,Ichihara, Yoshitatsu,Sato, Yoshio,Yamaji, Taketo,Tsuboi, Hiroshi,Murata, Natsuko,Uchida, Masayuki,Shimamura, Mariko,Oikawa, Tsutomu
, p. 421 - 423 (1997)
A new anti-angiogenic agent, 17α-acetoxy-9α-fluoro-6α- methylprogesterone (9α-fluoromedroxyprogesterone acetate [FMPA, 9]) was synthesized in a 10-step sequence. FMPA (9) had about two orders of magnitude stronger antiangiogenic activity than medroxyprogesterone acetate (MPA), as estimated in a bioassay involving chorioallantoic membranes of growing chick embryos.
Progesterone compound and use thereof
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, (2008/06/13)
A progesterone compound represented by the following formula (1): STR1 ?wherein R1 represents a C1-C23 hydrocarbon group!, and a neovascularization inhibitor containing the same as the active ingredient. The compound (1) has a potent neovascularization inhibitory effect and is hence useful in the treatment of malignant tumors, diabetic retinitis, rheumatism, etc.