17163-22-3

Basic information

• Product Name: NSC 178900
• Synonyms: 3-(5-Nitro-2-thienyl)-2-propenoic Acid;3-(5-Nitro-2-thiophene)acrylic Acid;5-Nitro-2-thiopheneacrylic Acid;NSC 178900;3-(5-Nitrothiophen-2-yl)acrylic acid;(E)-3-(5-nitrothiophen-2-yl)prop-2-enoic acid
• CAS NO: 17163-22-3
• Molecular Formula: C7H5NO4S
• Molecular Weight: 199.1839
• Mol File: 17163-22-3.mol
• Article Data: 3

Chemical Properties

• Melting Point: 251-252 °C (decomp)(Solv: ethanol (64-17-5))
• Boiling Point: 392.2°Cat760mmHg
• Flash Point: 191°C
• Appearance: /
• Density: 1.576g/cm³
• Vapor Pressure: 7.46E-07mmHg at 25°C
• Refractive Index: 1.696
• Storage Temp.: 2-8°C(protect from light)
• Solubility: Dichloromethane, DMSO, Methanol
• PKA: 3.90±0.10(Predicted)
• CAS DataBase Reference: NSC 178900(CAS DataBase Reference)
• NIST Chemistry Reference: NSC 178900(17163-22-3)
• EPA Substance Registry System: NSC 178900(17163-22-3)

Safety Data

• Hazardous Substances Data: 17163-22-3(Hazardous Substances Data)

Usage

Chemical Properties

Brown Solid

Uses

Nitrated thiophene derivative. Parasiticide. Intermediate in the synthesis of Nercrosulfonamide (N388600) analogue.

InChI:InChI=1/C7H5NO4S/c9-7(10)4-2-5-1-3-6(13-5)8(11)12/h1-4H,(H,9,10)/b4-2+

Upstream product

• 50981-19-6 (5-nitro-2-thienyl)methylenemalonic acid 
• 4521-33-9 5-nitro-2-thiophenecarboxaldehyde 
• 141-82-2 malonic acid 

Downstream Products

• 1344724-53-3 C₁₅H₁₁N₅O₃S 

Relevant articles and documents

New fluorescent crosslinked aromatic polyamides containing thiopheneand furane in their backbone

New fluorescent crosslinked aromatic polyamides containing phenylen, thiophene and furane groups in the main chain were synthesized by self-condensation from 3-(5-aminothiophen-2-yl)propenoic acid, 3-(5-aminofuran-2-yl)propenoic acid and 3-(4-((5-aminothiophen-2-yl)methyleneamino)phenyl)propenoic acid using the phosphorylation method and triphenylphosphite as initiator. The amino compounds were obtained from 3-(5-nitrothiophen-2-yl)propenoic acid, 3-(5-nitrofuran-2-yl)propenoic acid and 3-(4-((5-nitrothiophen-2-yl)methyleneamino)phenyl)propenoic by selective reduction of each nitro group and was confirmed by 1H-NMR and FT-IR spectroscopy. Crosslinking of polyamides ocurr by mechanism between vinyl side groups reacts with the vinyl carbon of another chain, giving rise to interchain linear crosslinking. Depending on the structure the polymers have higher degree of crosslinking. Some vinyl groups react by thermal treatmentat 200 °C. Partially crosslinked polyamides with high emission fluorescence were obtained. Consequently amide bond formation, crosslinking and conjugation are the main factors that influence the fluorescence process. While polymers have several factors that affect the fluorescence, we believe that the most significant is the crosslinking of vinyl bonds. Subsequent thermal treatment of polyamides provoked crosslinking increase and fluorescence loss. The effect of the chemical structure was correlated with the thermal decomposition. Polyamides were characterized by UV-visible, FT-IR and 1H-NMR spectroscopy, inherent viscosity and thermogravimetric analysis (TGA). The synthesized polyamides exhibited potential for heat sensitive devices application since the fluorescence can be activated or quenched according to a heating process.

Studies on the synthesis of new antimicrobials. II. Syntheses of 3-(5-nitro-2-thienvl)acrvlic acid derivatives and thers ome antibacterial activities.

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