17165-16-1Relevant academic research and scientific papers
SYNTHESIS OF SOME CARBONYL DERIVATIVES OF TRIS(AMINOMETHYL)PHOSPHINE OXIDE
Frank, Arlen W.
, p. 265 - 276 (2007/10/02)
Miscellaneous phosphorylated carbamates, ureas and thioureas of potential value as flame retardants for cotton have been synthesized from a key intermediate, tris(aminomethyl)phosphine oxide (1), whose synthesis we recently described.Reactions were carrie
Synthesis of tris(aminomethyl)phosphine oxide and its carbon dioxide adduct from tetrakis(hydroxymetyl)phosphonium salts via their methyl carbamate derivatives
Frank, Arlen W.
, p. 27 - 33 (2007/10/02)
Tris(aminomethyl)phosphine oxide (6) can be synthesized from octakis(hydroxymethyl)diphosphonium sulfate (1b) in an overall yield of 54.6percent via the methyl carbamate derivatives 2b, 3, and 4.On a preparative scale, the last step is complicated by the formation of a cyclic by-product 8 in amounts up to 20percent of the total.The triamine 6 forms a 1:1 adduct (11) with carbon dioxide, whose structure, established by 1H and 13C nmr, consists of equimolar amounts of carbamate A and dicarbamate BC.The components A, B, and C can be separated by ion exchange.Thjermolysis of 11 regenerates 6 smoontly, providing a convenient method for purifying the triamine.
