171667-72-4Relevant academic research and scientific papers
Synthesis of thiosugars as weak inhibitors of glycosidases
Le Merrer, Yves,Fuzier, Myrielle,Dosbaa, Isabelle,Foglietti, Marie-Jose,Depezay, Jean-Claude
, p. 16731 - 16746 (2007/10/03)
A series of enantiomerically pure thiosugars (1,6-dideoxy-1,6-thio-D- mannitol or L-iditol, 1,5-dideoxy-1,5-thio-L-gulitol or D-glucitol and 2,5- dideoxy-2,5-thio-L-iditol or D-mannitol, and their corresponding sulfoxide or sulfone) was synthesized via thiocyclization of C2-symmetric bis-epoxides, and subsequently followed by ring isomerization in few cases. These compounds have been evaluated as inhibitors of several glycosidases (α- and β-D- glucosidases, α-D-mannosidase and α-L-fucosidase).
THIOSUGARS FROM D-MANNITOL
Fuzier, Myrielle,Merrer, Yves Le,Depezay, Jean-Claude
, p. 6443 - 6446 (2007/10/02)
Enantiomerically pure thiosugars, with a thiepan, tetrahydrothiopyran or tetrahydrothiophene backbone, have been synthesized by thio-heterocyclization of enantiopure C2-symmetric bis-epoxides and possibly ring contraction. - Key words: Thiosuga
