171775-76-1

Basic information

• Product Name: Boc-Ser(PO2)-OMBzl
• CAS NO: 171775-76-1
• Molecular Weight: 675.586
• Mol File: 171775-76-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Boc-Ser(PO2)-OMBzl(CAS DataBase Reference)
• NIST Chemistry Reference: Boc-Ser(PO2)-OMBzl(171775-76-1)
• EPA Substance Registry System: Boc-Ser(PO2)-OMBzl(171775-76-1)

Safety Data

• Hazardous Substances Data: 171775-76-1(Hazardous Substances Data)

Upstream product

• 3262-72-4 (S)-N-(tert-butoxycarbonyl)serine 
• 619-73-8 4-nitrobenzyl chloride 
• 171775-82-9 N-(tert-butoxycarbonyl)-L-serine 4-methoxybenzyl ester 
• 143057-36-7 N,N-diisopropyl-di(4-nitrobenzyl)phosphoramidite 

Relevant articles and documents

Preparation of phosphoamino acid derivatives with acid stable O-phosphono-protection for the Boc-mode solid-phase synthesis of phosphopeptides

Boc-phosphoamino acid derivatives with O-[di(4-nitrobenzyl)- or dicyclohexylphosphono]-protection were prepared for application to the Boc-mode solid-phase synthesis of phosphopeptides. These protecting groups are both stable to TFA, but removable with a combination of trifluoromethanesulfonic acid and methylthiobenzene in TFA. Of these derivatives, N(α)-Boc-O-(dicyclohexylphosphono)serine and N(α)-Boc-O-(dicyclohexylphosphono)threonine were obtained as crystalline compounds to be favorably utilized as starting materials for solid-phase synthesis using an automated peptide synthesizer. On the other hand, N(α)-Boc-O-(dicyclohexylphosphono)tyrosine and all of the O-[di(4-nitrobenzyl)]phosphono derivatives were prepared as crystalline cyclohexylammonium or dicyclohexylammonium salts.