171846-10-9

Upstream product

• 10406-25-4 4-aminobenzyl cyanide 
• 146621-94-5 (S)-1-((R)-2-(tert-butoxycarbonylamino)-2-cyclohexylacetyl)pyrrolidine-2-carboxylic acid 
• 104-85-8 para-methylbenzonitrile 
• 17201-43-3 4-cyanobenzyl bromide 
• 179816-47-8 (S)-tert-butyl 2-((4-cyanobenzyl)carbamoyl)pyrrolidine-1-carboxylate 
• 15996-76-6 4-cyanobenzylamine hydrochloride 
• 15761-39-4 1-(tert-butoxycarbonyl)-L-proline 
• 70491-05-3 (2R)-[(tert-butoxycarbonyl)-amino](cyclohexyl)ethanoic acid 
• 172348-74-2 tert-butyl ((tert-butoxycarbonyl)(4-cyanobenzyl)amino)-methanoate 

Downstream Products

• 1349554-82-0 C₂₆H₃₉N₅O₄ 
• 171846-11-0 (S)-1-((R)-2-Cyclohexyl-2-methanesulfonylamino-acetyl)-pyrrolidine-2-carboxylic acid 4-cyano-benzylamide 

Relevant academic research and scientific papers

Binding cooperativity between a ligand carbonyl group and a hydrophobic side chain can be enhanced by additional H-bonds in a distance dependent manner: A case study with thrombin inhibitors

One of the underappreciated non-covalent binding factors, which can significantly affect ligand-protein binding affinity, is the cooperativity between ligand functional groups. Using four different series of thrombin inhibitors, we reveal a strong positiv

Noncovalent tripeptidic thrombin inhibitors incorporating amidrazone, amine and amidine functions at P1

A series of noncovalent tripeptidic thrombin inhibitors incorporating amidrazone, amine and amidine functions at P1 was investigated. While the amidrazone and the amine series displayed limited oral absorption, the amidine series demonstrated generally good oral absorption and strong antithrombotic activity; the single-digit picomolar Ki achieved from this series is among the best yet reported. The present work highlights the benzamidine compound 11f (LB30812) that exhibits excellent overall profiles of potency, oral absorption and antithrombotic efficacy.