171846-10-9

Basic information

• Product Name: tert-butyl ((R)-1-((2S)-2-((4-cyanobenzyl)carbamoyl)pyrrolidin-1-yl)-1-cyclohexyl-2-oxoethyl)carbamate
• Synonyms: tert-butyl ((R)-1-((2S)-2-((4-cyanobenzyl)carbamoyl)pyrrolidin-1-yl)-1-cyclohexyl-2-oxoethyl)carbamate
• CAS NO: 171846-10-9
• Molecular Weight: 468.596
• Mol File: 171846-10-9.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: tert-butyl ((R)-1-((2S)-2-((4-cyanobenzyl)carbamoyl)pyrrolidin-1-yl)-1-cyclohexyl-2-oxoethyl)carbamate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl ((R)-1-((2S)-2-((4-cyanobenzyl)carbamoyl)pyrrolidin-1-yl)-1-cyclohexyl-2-oxoethyl)carbamate(171846-10-9)
• EPA Substance Registry System: tert-butyl ((R)-1-((2S)-2-((4-cyanobenzyl)carbamoyl)pyrrolidin-1-yl)-1-cyclohexyl-2-oxoethyl)carbamate(171846-10-9)

Safety Data

• Hazardous Substances Data: 171846-10-9(Hazardous Substances Data)

Upstream product

• 10406-25-4 4-aminobenzyl cyanide 
• 146621-94-5 (S)-1-((R)-2-(tert-butoxycarbonylamino)-2-cyclohexylacetyl)pyrrolidine-2-carboxylic acid 
• 104-85-8 para-methylbenzonitrile 
• 17201-43-3 4-cyanobenzyl bromide 
• 172348-74-2 tert-butyl ((tert-butoxycarbonyl)(4-cyanobenzyl)amino)-methanoate 
• 70491-05-3 (2R)-[(tert-butoxycarbonyl)-amino](cyclohexyl)ethanoic acid 
• 15761-39-4 1-(tert-butoxycarbonyl)-L-proline 
• 15996-76-6 4-cyanobenzylamine hydrochloride 
• 179816-47-8 (S)-tert-butyl 2-((4-cyanobenzyl)carbamoyl)pyrrolidine-1-carboxylate 

Downstream Products

• 1349554-82-0 C₂₆H₃₉N₅O₄ 
• 171846-11-0 (S)-1-((R)-2-Cyclohexyl-2-methanesulfonylamino-acetyl)-pyrrolidine-2-carboxylic acid 4-cyano-benzylamide 

Relevant articles and documents

Binding cooperativity between a ligand carbonyl group and a hydrophobic side chain can be enhanced by additional H-bonds in a distance dependent manner: A case study with thrombin inhibitors

One of the underappreciated non-covalent binding factors, which can significantly affect ligand-protein binding affinity, is the cooperativity between ligand functional groups. Using four different series of thrombin inhibitors, we reveal a strong positiv