171858-52-9Relevant academic research and scientific papers
Substrate-based cyclic peptidomimetics of Phe-Ile-Val that inhibit HIV-1 protease using a novel enzyme-binding mode
March, Darren R.,Abbenante, Giovanni,Bergman, Douglas A.,Brinkworth, Ross I.,Wickramasinghe, Wasantha,Begun, Jake,Martin, Jennifer L.,Fairlie, David P.
, p. 3375 - 3379 (2007/10/03)
Results are presented for inhibitors of HIV-1 protease that demonstrate a new strategy for developing peptidomimetics, involving the replacement of flexible segments of peptide substrates with conformationally constrained hydrolytically-stable macrocyclic
