171877-91-1

Upstream product

• 171877-93-3 4-deoxy-4-(adenin-9-yl)-2,5-anhydro-L-mannofuranose dimethylacetal 
• 495-75-0 2,5-anhydro-D-mannose 
• 41107-82-8 2,5-anhydro-D-mannitol 
• 86363-73-7 (2R,3S,4S,5R)-3,4-dihydroxy(tetrahydrofuran-2,5-diyl)bis(methylene) dibenzoate 
• 1078691-95-8 (+)-D-glucosamine hydrochloride 
• 91318-12-6 2,5:3,4-dianhydro-1,6-di-O-benzoyl-D-altritol 
• 66224-66-6 adenine 
• 171877-92-2 2,5:3,4-dianhydro-L-talofuranose dimethylacetal 
• 196596-83-5 3-O-p-tolylsulfonyl-2,5-anhydro-L-idofuranose dimethylacetal 

Relevant academic research and scientific papers

Synthesis of 3-deoxy-3-nucleobase-2,5-anhydro-D-mannitol: A novel class of hydroxymethyl-branched isonucleosides

A concise synthesis of 3-deoxy-3-nucleobase-2,5-anhydro-D-mannitol 6(a- d) has been achieved, using the deamination of 2-amino-2-deoxy-D-glucose to construct in one step the sugar skeleton with the desired sense of chirality at each asymmetric center. The selective dibenzoylation of 2,5-anhydro-D- mannitol 9 was investigated, and the key epoxide intermediate 13 was obtained in good yield via an intramolecular Mitsunobu reaction. The process of opening of epoxide 13 by nucleobases appeared to be regioselective. (C) 2000 Elsevier Science Ltd.

Stereoselective synthesis of 4-deoxy-4-nucleobase-2,5-anhydro-L-mannitol derivatives

2,5:3,4-Dianhydro-L-talofuranose dimethylacetal 7 was synthesized from D-glucose in 7 steps. A series of 4-deoxy-4-nucleobase-2,5-anhydro-L-mannitols 13-16 were synthesized regioselectively from 7 in good yields. 6-O-p-Tolylsulfonyl-2,5:3,4-dianhydro-L-ta