171889-34-2

Upstream product

• 171889-25-1 (S)-3-((1R,2S)-2-Diethylcarbamoyl-2-phenyl-cyclopropyl)-3-hydroxy-propionic acid ethyl ester 
• 172016-00-1 (1S,2R)-2-Formyl-1-phenyl-cyclopropanecarboxylic acid diethylamide 

Downstream Products

• 171889-26-2 2,2-Dimethyl-propionic acid (S)-3-((1R,2S)-2-diethylcarbamoyl-2-phenyl-cyclopropyl)-3-hydroxy-propyl ester 
• 171889-33-1 [(S)-1-((1R,2S)-2-Diethylcarbamoyl-2-phenyl-cyclopropyl)-allyl]-carbamic acid tert-butyl ester 
• 171889-11-5 (1S,2R)-2-((S)-1-Amino-allyl)-1-phenyl-cyclopropanecarboxylic acid diethylamide 
• 171889-29-5 (1S,2R)-1-phenyl-2-[(S)-1-azido-3-tosyloxypropyl]-N,N-diethylcyclopropanecarboxamide 
• 171889-32-0 [(S)-1-((1R,2S)-2-Diethylcarbamoyl-2-phenyl-cyclopropyl)-3-phenylselanyl-propyl]-carbamic acid tert-butyl ester 
• 171889-27-3 2,2-Dimethyl-propionic acid (S)-3-azido-3-((1R,2S)-2-diethylcarbamoyl-2-phenyl-cyclopropyl)-propyl ester 
• 171889-30-8 (1S,2R)-2-((S)-1-Azido-3-phenylselanyl-propyl)-1-phenyl-cyclopropanecarboxylic acid diethylamide 
• 171889-31-9 (1S,2R)-2-((S)-1-Amino-3-phenylselanyl-propyl)-1-phenyl-cyclopropanecarboxylic acid diethylamide 
• 171889-28-4 (1S,2R)-1-phenyl-2-[(S)-1-azido-3-hydroxypropyl]-N,N-diethylcyclopropanecarboxamide 
• 171889-07-9 (1S,2R)-1-phenyl-2-[(S)-1-aminopropyl]-N,N-diethylcyclopropanecarboxamide 

Relevant academic research and scientific papers

Synthesis and biological activity of conformationally restricted analogs of milnacipran: (1S,2A)-1-Phenyl-2-[(S)-1-aminopropyl]-N,N-diethylcyclopropanecarboxamide, an efficient noncompetitive N-methyl-D-aspartic acid receptor antagonist

We recently demonstrated that (±)-(Z)-2-(aminomethyl)-1-phenyl-N,N-diethylcyclopropanecarboxamide [milnacipran, (±)-1], an inhibitor of the reuptake of serotonin (5-HT), was a noncompetitive NMDA receptor antagonist. On the basis of the cyclopropane struc