17199-33-6Relevant academic research and scientific papers
Discovery of a potent enoyl-acyl carrier protein reductase (FabI) inhibitor suitable for antistaphylococcal agent
Kim, Yun Gyeong,Seo, Jae Hong,Kwak, Jin Hwan,Shin, Kye Jung
, p. 4481 - 4486 (2015)
We report the discovery, synthesis, and biological activities of phenoxy-4-pyrone and phenoxy-4-pyridone derivatives as novel inhibitors of enoyl-acyl carrier protein reductase (FabI). Pyridone derivatives showed better activities than pyrone derivatives
Discovery of amino-acetonitrile derivatives, a new class of synthetic anthelmintic compounds
Ducray, Pierre,Gauvry, Noelle,Pautrat, Francois,Goebel, Thomas,Fruechtel, Joerg,Desaules, Yves,Weber, Sandra Schorderet,Bouvier, Jacques,Wagner, Trixie,Froelich, Olivier,Kaminsky, Ronald
, p. 2935 - 2938 (2008/12/22)
A new series of amino-acetonitrile derivatives (AAD) have been discovered that exhibit high anthelmintic activity against parasitic nematode species such as Haemonchus contortus and Trichostrongylus colubriformis. Significantly, these compounds also demonstrate activity against nematode strains resistant to the currently available broad-spectrum anthelmintics. The discovery, synthesis, structure-activity relationship and biological results are presented.
