172093-34-4

Basic information

• Product Name: methyl 4-(acetylamino)-2-(n-propoxy)benzoate
• CAS NO: 172093-34-4
• Molecular Weight: 251.282
• Mol File: 172093-34-4.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: methyl 4-(acetylamino)-2-(n-propoxy)benzoate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 4-(acetylamino)-2-(n-propoxy)benzoate(172093-34-4)
• EPA Substance Registry System: methyl 4-(acetylamino)-2-(n-propoxy)benzoate(172093-34-4)

Safety Data

• Hazardous Substances Data: 172093-34-4(Hazardous Substances Data)

Upstream product

• 106-94-5 propyl bromide 
• 4093-28-1 methyl 4-acetamido-2-hydroxybenzoate 
• 4136-97-4 methyl 4-aminosalicylate 
• 65-49-6 4-Aminosalicylic acid 
• 107-08-4 1-iodo-propane 

Downstream Products

• 1028126-99-9 C₁₃H₁₆N₂O₆ 
• 1388193-72-3 C₁₃H₁₆BrNO₄ 
• 1388193-74-5 C₁₀H₁₂BrNO₃ 
• 1388193-83-6 C₁₂H₁₅Br₂NO₃ 
• 1388193-71-2 C₁₂H₁₅BrClNO₃ 
• 1388193-76-7 C₁₃H₁₇BrClNO₃ 
• 1388193-85-8 C₁₃H₁₇Br₂NO₃ 
• 1388193-53-0 Br^(1-)*C₃₂H₃₆ClN₂O₇⁽¹⁺⁾ 
• 1388193-56-3 Br^(1-)*C₃₃H₃₈ClN₂O₇⁽¹⁺⁾ 
• 1388193-63-2 Br^(1-)*C₃₂H₃₆BrN₂O₇⁽¹⁺⁾ 
• 1388193-65-4 Br^(1-)*C₃₃H₃₈BrN₂O₇⁽¹⁺⁾ 
• 172093-36-6 4-amino-5-chloro-2-(n-propoxy)benzoic acid 
• 172093-35-5 methyl 4-(acetylamino)-5-chloro-2-(n-propoxy)benzoate 
• 2486-79-5 4-amino-2-propoxy-benzoic acid 

Relevant articles and documents

Synthesis and biological evaluation of berberine derivatives as IBS modulator

Irritable bowel syndrome is the most common functional gastrointestinal disorder characterized by chronic abdominal pain or discomfort in association with a change in bowel habit. 5-HT receptor modulators have been developed as IBS therapeutic agents and proved to be effective in the treatment of the disease. In this letter, 12 berberine derivatives were designed and synthesized as 5-HT receptor modulators. Preliminary biological tests suggested that the new compounds exhibited promising activity for IBS therapy.

Development of potent serotonin-3 (5-HT3) receptor antagonists. I. Structure-activity relationships of 2-alkoxy-4-amino-5-chlorobenzamide derivatives

A new series of 2-alkoxy-4-amino-5-chlorobenzamide derivatives hearing five- to seven-membered heteroalicyclic rings in the amine moiety was synthesized and evaluated for serotonin-3 (5-HT3) receptor antagonistic activity by assaying the ability to antagonize the yon Bezold-Jarisch reflex in rats. The five- to seven-membered heteroalicycles comprise pyrrolidine, morpholine, 1,4-thiazine, piperidine, piperazine, 1,4-oxazepine, 1,4- thiazepine, azepine, and 1,4-diazepine rings. Among them, some benzamide derivatives having a 1,4-diazepine ring showed a potent 5-HT3 receptor antagonistic activity. In particular, 4-amino-5-chloro-N-(1,4- dimethylhexahydro-1H-1,4-diazepin-6-yl)-2-ethoxyhenzamide (96) and the 1- benzyl-4-methylhexahydro-1H-1,4-diazepine analogue 103 showed potent 5-HT3 receptor antagonistic activity without 5-HT4 receptor binding affinity.