172097-51-7

Basic information

• Product Name: (2S,3S)-1-p-methoxybenzyloxy-3-tertbutoxycarbonylamino-2-butanol
• CAS NO: 172097-51-7
• Molecular Weight: 325.405
• Mol File: 172097-51-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (2S,3S)-1-p-methoxybenzyloxy-3-tertbutoxycarbonylamino-2-butanol(CAS DataBase Reference)
• NIST Chemistry Reference: (2S,3S)-1-p-methoxybenzyloxy-3-tertbutoxycarbonylamino-2-butanol(172097-51-7)
• EPA Substance Registry System: (2S,3S)-1-p-methoxybenzyloxy-3-tertbutoxycarbonylamino-2-butanol(172097-51-7)

Safety Data

• Hazardous Substances Data: 172097-51-7(Hazardous Substances Data)

Upstream product

• 154079-54-6 (2S,3S)-3-tert-butoxycarbonylamino-1,2-butanediol 
• 24424-99-5 di-tert-butyl dicarbonate 

Relevant articles and documents

Enantioselective Synthesis of Fully Protected anti 3-Amino-2-Hydroxy Butyrates

An efficient enantioselective synthesis of fully protected anti 3-amino-2-hydroxybutyrates has been developed.Starting from enantiomerically enriched anti N-diphenylmethyl-3-amino-1,2-butanediol, after a change in the nitrogen protecting group, the primary alcohol was protected by regioselective reduction of the corresponding p-methoxybenzylidene acetal.Formation of the oxazolidine and deprotection of the primary alcohol followed by oxidation afforded protected α-hydroxy-β-amino acids in good yield.Since the source of asymmetry is a catalytic Sharpless epoxidation, both enantiomeric series are available and the methodology developed here is expected to be of broad applicability.