1721-82-0

Upstream product

• 58811-64-6 N-(2-hydroxy-2,2-diphenyl-ethyl)-acetamide 
• 1722-89-0 N-(2,2-diphenylvinyl)acetamide 
• 94675-09-9 (+/-)-N-(erythro-α'-methoxy-bibenzyl-α-yl)-acetamide 
• 10025-87-3 trichlorophosphate 
• 71-43-2 benzene 
• 613-91-2 acetophenone oxime 
• 536-74-3 phenylacetylene 
• 873838-37-0 2-cyanophenyl 1,1,2,2,3,3,4,4,4-nonafluorobutane-1-sulfonate 
• 17336-68-4 N'-(2-methoxy-1-phenylethylidene)-4-methylbenzenesulfonohydrazide 
• 917-54-4 methyllithium 
• 686719-30-2 2-(2-methoxy-1-phenylethenyl)benzonitrile 
• 119-65-3 isoquinoline 
• 1616735-04-6 1-(1-methylisoquinolin-2(1H)-yl)ethan-1-one 
• 1616735-06-8 1-(1-methyl-4-phenylisoquinolin-2(1H)-yl)ethanone 

Downstream Products

• 88474-11-7 (E)-2-Hydroxy-3-(4-phenyl-isoquinolin-1-yl)-acrylic acid ethyl ester 
• 88474-14-0 3-(4-Phenyl-isoquinolin-1-ylmethyl)-1H-quinoxalin-2-one 

Relevant academic research and scientific papers

Palladium catalyzed, heteroatom-guided C-H functionalization in the synthesis of substituted isoquinolines and dihydroisoquinolines

A new approach for the functionalization of C-4 of isoquinolines is reported. The method utilizes palladium catalyzed, hetero-atom guided (or electrophilic metalation) direct arylation via regioselective C-H functionalization of dihydroisoquinolines.

Synthesis of polysubstituted isoquinolines through cross-coupling reactions with α-alkoxytosylhydrazones

A Pd-catalyzed cross-coupling reaction of α-alkoxytosylhydrazones with sulfonates derived from salicyl aldehydes gives rise to protected 1,5-dicarbonyl compounds. Treatment with ammonium hydroxide readily transforms these alkenes into isoquinolines with d

Easy access to isoquinolines and tetrahydroquinolines from ketoximes and alkynes via rhodium-catalyzed C-H bond activation

(Chemical Equation Presented) Described herein is a convenient and highly regioselective synthesis of substituted isoquinoline derivatives from various aromatic ketoximes and alkynes via a one-pot, rhodium-catalyzed C-H bond activation. In addition, tetra

Isoquinoline syntheses via Δ2-oxazolines. Part VIII cyclization of 2-acetamido-1,2-diphenylethan-1-ol derivatives into isoquinoline systems

The results of the conversion of 2-acetamido-1,2-diphenylethan-1-ol derivatives (1) into 1-methyl-4-phenylisoquinoline derivatives (2) have been described. The mechanism proposed for these reaction assumes the existence of protonated Δ2-oxazolines (3), carbonium ions (4), and unsafurated amides (5 and 6) as intermediates.

Synthesis and Transformations of 1-Methyl-4-aryl-7-R-isoquinolines

1-Methyl-4-aryl-7-R-isoquinolines were obtained by cyclization of 1,1-diaryl-2-acetamidoethylenes in the presence of phosphorus pentoxide.The condensation of the products with diethyl oxalate leads to the formation of ethyl 1-(4-aryl-7-R-isoquinolyl)pyruv