172163-62-1

Basic information

• Product Name: 7-DEAZA-7-IODO-2'-DEOXYGUANOSINE
• Synonyms: 7-DEAZA-7-IODO-2'-DEOXYGUANOSINE;7-Deaza-2'-deoxy-7-iodoguanosine;7-Deaza-7-I-2'-dA;7-Deaza-21-deoxy-7-iodoguanosine;7-Deaza-7-I-2'-dG;2-AMino-7-((2R,4S,5R)-4-hydroxy-5-(hydroxyMethyl)tetrahydrofuran-2-yl)-5-iodo-1H-pyrrolo[2,3-d]pyriMidin-4(7H)-one;2-amino-7-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-iodo-3H-pyrrolo[2,3-d]pyrimidin-4(7H)-one;7-iodo-7-deaza-2'-deoxyguanosine
• CAS NO: 172163-62-1
• Molecular Formula: C₁₁H₁₃IN₄O₄
• Molecular Weight: 392.15
• EINECS: 2017-001-1
• Mol File: 172163-62-1.mol
• Article Data: 8

Chemical Properties

• Appearance: /
• Density: 2.49±0.1 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• Solubility: DMSO (Slightly, Heated, Sonicated), Methanol (Slightly, Heated, Sonicated)
• PKA: 10.28±0.20(Predicted)
• CAS DataBase Reference: 7-DEAZA-7-IODO-2'-DEOXYGUANOSINE(CAS DataBase Reference)
• NIST Chemistry Reference: 7-DEAZA-7-IODO-2'-DEOXYGUANOSINE(172163-62-1)
• EPA Substance Registry System: 7-DEAZA-7-IODO-2'-DEOXYGUANOSINE(172163-62-1)

Safety Data

• Hazardous Substances Data: 172163-62-1(Hazardous Substances Data)

Usage

General Description

7-DEAZA-7-IODO-2'-DEOXYGUANOSINE is a chemical compound that belongs to the class of deoxyribonucleosides and nucleotides. It is a modified form of the nucleoside guanosine, with a 7-iodo and a 7-deaza substitution. 7-DEAZA-7-IODO-2'-DEOXYGUANOSINE has been studied for its potential use in antiviral and anticancer therapies, as well as in biochemical research. It has also been investigated for its ability to inhibit the replication of certain viruses, including hepatitis C virus. Additionally, 7-DEAZA-7-IODO-2'-DEOXYGUANOSINE has shown potential as a radiolabeled probe for studying DNA-binding proteins and RNA polymerases. Overall, this compound has promising applications in medicine and biomedical research.

Upstream product

• 86392-74-7 2-amino-9-(2'-deoxy-β-D-erythro-pentofuranosyl)-6-methoxyl-7H-pyrrolo[2,3-d]pyrimidine 
• 174462-91-0 7-[2-deoxy-β-D-erythro-pentofuranosyl]-5-iodo-2-(isobutyrylamino)-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one 
• 84955-31-7 4-chloro-7H-pyrrolo[2,3-d]pyrimidin-2-amine 
• 7355-55-7 2-amino-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one 
• 866331-10-4 N-(4-chloro-7H-pyrrolo[2,3-d]pyrimidin-2-yl)isobutyramide 
• 220036-88-4 2-amino-7-(2-deoxy-β-D-erythro-pentofuranosyl)-3,7-dihydro-5-iodo-4-methoxy-4H-pyrrolo[2,3-d]pyrimidine 
• 172163-59-6 Isobutyric acid (2R,3S,5R)-5-(2-formylamino-5-iodo-4-methoxy-pyrrolo[2,3-d]pyrimidin-7-yl)-2-isobutyryloxymethyl-tetrahydro-furan-3-yl ester 

Downstream Products

• 174462-91-0 7-[2-deoxy-β-D-erythro-pentofuranosyl]-5-iodo-2-(isobutyrylamino)-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one 
• 1529801-43-1 2-amino-7-(2-deoxy-β-D-erythro-pentofuranosyl)-5-[2-(1-ethynylpyrenyl)]-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one 
• 1472616-80-0 7-[2-deoxy-5-O-(4,4′-dimethoxytrityl)-β-D-erythro-pentofuranosyl]-5-ethynyl-3,7-dihydro-2-(isobutyrylamino)-4H-pyrrolo[2,3-d]pyrimidin-4-one 3′-(2-cyanoethyl)-N,N-diisopropylphosphoramidite 
• 1432489-04-7 2'-deoxy-5-(3-nitrophenyl)-7-deazaguanosine 
• 1332831-25-0 C₃₈H₂₅N₅O₄ 
• 1332831-28-3 C₄₁H₃₀N₆O₄ 
• 1288999-19-8 2-N-(N,N-dimethylaminomethylidenyl)-N₃-benzoyl-7-deaza-7-iodo-3'-O-(2-cyanoethyl)-2'-deoxyguanosine 
• 1288998-95-7 2-N-(N,N-dimethylaminomethylidenyl)-N₁-benzoyl-7-deaza-7-iodo-3'-O-(2-cyanoethyl)-5'-O-(4-monomethoxytrityl)-2'-deoxyguanosine 
• 1288998-94-6 2-N-(N,N-dimethylaminomethylidenyl)-N₁-benzoyl-7-deaza-7-iodo-5'-O-(4-monomethoxytrityl)-2'-deoxyguanosine 
• 1288998-93-5 2-N-(N,N-dimethylaminomethylidenyl)-N₁-benzoyl-7-deaza-7-iodo-2'-deoxyguanosine 
• 1288999-14-3 2-N-(N,N-dimethylaminomethylidenyl)-N₁-benzoyl-7-deaza-7-iodo-3',5'-O-(tetraisopropyldisiloxane-1,3-diyl)-2'-deoxyguanosine 
• 196925-94-7 N-{7-{(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-4-oxo-5-[5-(2,2,2-trifluoro-acetylamino)-pent-1-ynyl]-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-2-yl}-isobutyramide 

Relevant articles and documents

7-Substituted 7-deaza-2'-deoxyguanosines: Regioselective halogenation of pyrrolo[2,3-d]pyrimidine nucleosides

The synthesis of 7-chloro-, 7-bromo-, and 7-iodo-substituted 7-deaza-2'-deoxyguanosine derivatives 2b-d is described. The regioselective 7-halogenation with N-halogenosuccinimides was accomplished using 7-[2-deoxy-3,5-O-di(2-methylpropanoyl)-β-D-erythro-pentofuranosyl]-2- formylamino)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidine (4) as the common precursor. A one-pot reaction (2N aq. NaOH) of the halogenated intermediates 5a-c furnished the desired compounds. Also the 7-hexynyl derivative 2e of 7-deaza-2'-deoxyguanosine is described.

7-the to nitrogen -2 [...] -deoxy-7-halogen-substituted guanine nucleoside synthesis method

The invention discloses a synthetic method of 7-denitrified-2'-deoxidized-7-halogen substituted guanosine; the method comprises the following steps: a compound in the following formula (I) is obtained from a compound in the following formula (V) by demeth

7-to nitrogen-7-halogen-guanine nucleoside synthesis method

The invention discloses a method for synthesizing 7-denitrification-7-halogen guanosine. The method comprises the following steps: removing a protecting group of a compound of the formula (III) under an alkali condition so as to obtain a compound of the f