172216-93-2

Basic information

• Product Name: 1-<2-(trifluoromethyl)phenyl>-1-phenylhydrazine
• CAS NO: 172216-93-2
• Molecular Weight: 252.239
• Mol File: 172216-93-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-<2-(trifluoromethyl)phenyl>-1-phenylhydrazine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-<2-(trifluoromethyl)phenyl>-1-phenylhydrazine(172216-93-2)
• EPA Substance Registry System: 1-<2-(trifluoromethyl)phenyl>-1-phenylhydrazine(172216-93-2)

Safety Data

• Hazardous Substances Data: 172216-93-2(Hazardous Substances Data)

Upstream product

• 172216-92-1 α,α,α-trifluoro-N-nitroso-N-phenyl-o-toluidine 
• 108-86-1 bromobenzene 
• 392-83-6 o-trifluoromethylphenyl bromide 
• 344-62-7 N-[2-(trifluoromethyl)phenyl]acetamide 
• 172216-91-0 α,α,α-trifluoro-N-phenyl-o-acetotoluidide 
• 103-84-4 Acetanilid 
• 14925-11-2 α,α,α-trifluoro-N-phenyl-o-toluidine 
• 172217-04-8 α,α,α-trifluoro-o-diacetotoluidide 

Downstream Products

• 172216-94-3 ethyl pyruvate 2-<2-(trifluoromethyl)phenyl>phenylhydrazone 

Relevant articles and documents

Fischer indolization of ethyl pyruvate 2-[2- (trifluoromethyl)phenyl]phenylhydrazone and new insight into the mechanism of the Goldberg reaction. (Fischer indolization and its related compounds. XXVI)

The Fischer indolization of ethyl pyruvate 2-[2- (trifluoromethyl)phenyl]phenylhydrazone (5) gave two indolic products, ethyl 7-(trifluoromethyl)-1-phenylindole-2-carboxylate (12) as a minor product and ethyl 1-[2-(trifluoromethyl)phenyl]indole-2-carboxylate (13) as a major product. This result shows that the Fischer indolization occurred on the more electron-rich phenyl group. In the Goldberg reaction to prepare 13 from ethyl indole-2-carboxylate (15) and o- (21) or m-bromo-α,α,α-trifluorotoluene (23), it was found that Goldberg reaction proceeds via a benzyne mechanism, at least in part, in a sterically crowded situation.