172261-05-1

Basic information

• Product Name: 2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)ethanethioamide
• Synonyms: 2-(1,3-dioxoisoindolin-2-yl)thioacetamide;2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)ethanethioamide;2-(1,3-diketoisoindolin-2-yl)thioacetamide;2-(1,3-dioxo-2-isoindolinyl)thioacetamide;2-(1,3-dioxoisoindol-2-yl)ethanethioamide
• CAS NO: 172261-05-1
• Molecular Formula: C₁₀H₈N₂O₂S
• Molecular Weight: 220.25
• Mol File: 172261-05-1.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)ethanethioamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)ethanethioamide(172261-05-1)
• EPA Substance Registry System: 2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)ethanethioamide(172261-05-1)

Safety Data

• Hazard Codes: Xi
• Statements: 36
• Safety Statements: 26
• Hazardous Substances Data: 172261-05-1(Hazardous Substances Data)

Usage

Structure

Contains a thiol group, an ethyl group, and an isoindole ring structure

Type

Thioamide derivative

Usage

Organic synthesis and pharmaceutical research

Potential

Exhibits potential biological activity

Applications

May have applications in medicinal chemistry for the development of new drugs or as a reagent in organic chemistry reactions

Importance

Properties and potential applications make it a subject for further research and exploration in various scientific fields.

Upstream product

• 3842-20-4 N-(cyanomethyl)phthalimide 
• 85-44-9 phthalic anhydride 
• 298-06-6 O,O-Diethyl hydrogen phosphorodithioate 

Downstream Products

• 1429312-33-3 2-[[4-(3-chlorophenyl)thiazol-2-yl]methyl]isoindoline-1,3-dione 
• 1138033-62-1 2-{[4-(2-fluorophenyl)-5-(phenylthio)-1,3-thiazol-2-yl]methyl}-1H-isoindole-1,3(2H)-dione 
• 952191-74-1 2-{[4-phenyl-5-(phenylthio)-1,3-thiazol-2-yl]methyl}-1H-isoindole-1,3(2H)-dione 

Relevant articles and documents

New thiazole derivatives as potent and selective 5-hydroxytriptamine 3 (5-HT3) receptor agonists for the treatment of constipation

The syntheses and biological evaluation of a series of novel indeno[1,2-d]thiazole derivatives are described. Several groups reported 5-HT3 receptor agonists which were mainly evaluated for their activities on the von Bezold-Jarisch reflex (B-J reflex). We discovered that tetrahydrothiazolopyridine derivative 1b had a contractile effect on the isolated guinea pig colon with weak B-J reflex. Our efforts to find a new type of 5-HT3 receptor agonists on the isolated guinea pig colon focused on the synthesis of a fused thiazole derivative 1d modified from 1b and reverse-fused thiazole derivatives (7-10). In this series, 10f (YM-31636) showed high affinity and selectivity for the cloned human 5-HT3 receptor; furthermore, it showed potent and selective 5-HT3 receptor agonistic activity. YM-31636 was examined for its effects on defecation in animals, thus evaluating the compound as an agent against constipation.

5-MEMBERED HETEROCYCLIC COMPOUND

Provided is a compound having a superior acid secretion suppressive action, which shows an antiulcer activity and the like. A compound represented by the formula (I) or a salt thereof: wherein ring A is a saturated or unsaturated 5-membered heterocycle co

ACID SECRETION INHIBITOR

The present invention provides a compound having a superior acid secretion inhibitory action, an antiulcer activity and the like. A proton pump inhibitor containing a compound represented by the formula (I) wherein ring A is a saturated or unsaturated 5- or 6-membered ring group optionally having, as a ring-constituting atom besides carbon atom, 1 to 4 hetero atoms selected from a nitrogen atom, an oxygen atom and a sulfur atom, ring-constituting atoms X1 and X2 are each a carbon atom or a nitrogen atom, a ring-constituting atom X3 is a carbon atom, a nitrogen atom, an oxygen atom or a sulfur atom, R1 is an optionally substituted aryl group or an optionally substituted heteroaryl group, R2 is an optionally substituted alkyl group, an optionally substituted aryl group or an optionally substituted heteroaryl group, R3 is an aminomethyl group optionally substituted by 1 or 2 lower alkyl groups, which is a substituent on a ring-constituting atom other than X1, X2 and X3, and ring A optionally further has substituent(s) selected from a lower alkyl group, a halogen atom, a cyano group and an oxo group, or a salt thereof or a prodrug thereof.