172268-78-9

Upstream product

• 198192-50-6 1-[(2S,4S,6S)-4-(tert-Butyl-diphenyl-silanyloxy)-6-methoxy-tetrahydro-pyran-2-yl]-but-2-yn-1-one 
• 172268-40-5 (E)-(S)-4-[(2S,4S,6S)-4-(tert-Butyl-diphenyl-silanyloxy)-6-methoxy-tetrahydro-pyran-2-yl]-2-methyl-pent-3-en-1-ol 
• 172268-61-0 (2S,4S,6S)-4-(tert-Butyl-diphenyl-silanyloxy)-6-((E)-(S)-4-hydroxy-1,3-dimethyl-but-1-enyl)-tetrahydro-pyran-2-ol 
• 172268-39-2 (Z)-(R)-2-[(2S,4S,6S)-4-(tert-Butyl-diphenyl-silanyloxy)-6-methoxy-tetrahydro-pyran-2-yl]-pent-3-en-2-ol 
• 172268-60-9 (R)-2-[(2S,4S,6S)-4-(tert-Butyl-diphenyl-silanyloxy)-6-methoxy-tetrahydro-pyran-2-yl]-pent-3-yn-2-ol 
• 172587-76-7 (2S,4S,6S)-4-(tert-Butyl-diphenyl-silanyloxy)-6-methoxy-tetrahydro-pyran-2-carbaldehyde 
• 172268-49-4 (7E,13E)-(1R,5R,9R,11R,12S,15S,17S)-17-(tert-Butyl-diphenyl-silanyloxy)-11-hydroxy-1-methoxy-8,10,10,12,14-pentamethyl-5-pentyl-9-triethylsilanyloxy-4,19-dioxa-bicyclo[13.3.1]nonadeca-7,13-dien-3-one 
• 79271-56-0 triethylsilyl trifluoromethyl sulfonate 
• 172268-63-2 [(2R,4S,6S)-4-(tert-Butyl-diphenyl-silanyloxy)-6-((E)-(S)-1,3-dimethyl-4-triethylsilanyloxy-but-1-enyl)-2-hydroxy-tetrahydro-pyran-2-yl]-acetic acid ethyl ester 
• 198192-49-3 (S)-3-(tert-Butyl-diphenyl-silanyloxy)-4-((S)-2,2-diethyl-[1,3]dioxolan-4-yl)-butyraldehyde 
• 198193-01-0 tert-Butyl-[(R)-1-((S)-2,2-diethyl-[1,3]dioxolan-4-ylmethyl)-but-3-enyloxy]-diphenyl-silane 
• 172268-53-0 [(2R,4S,6S)-4-(tert-Butyl-diphenyl-silanyloxy)-6-((E)-(3S,4R)-5-ethylsulfanylcarbonyl-4-hydroxy-1,3,5-trimethyl-hex-1-enyl)-2-methoxy-tetrahydro-pyran-2-yl]-acetic acid ethyl ester 
• 172587-77-8 2β-methoxy-4β-(diphenyl t-butylsiloxy)-6α-hydroxymethyl-tetrahydro-2H-pyran 
• 172268-47-2 [(2R,4S,6S)-4-(tert-Butyl-diphenyl-silanyloxy)-2-methoxy-6-((1E,7E)-(3S,4R,10R)-1,3,5,5,7-pentamethyl-6-oxo-4,10-bis-triethylsilanyloxy-pentadeca-1,7-dienyl)-tetrahydro-pyran-2-yl]-acetic acid ethyl ester 

Relevant academic research and scientific papers

Total synthesis of (+)-acutiphycin

(Chemical Equation Presented) Synthetic studies toward the total synthesis of (+)-acutiphycin (1) resulted in the discovery of additive-free, highly regioselective nickel-catalyzed reductive coupling reactions of aldehydes and 1,6-enynes and the construct

Total syntheses of (+)-acutiphycin and (+)-trans-20,21-didehydroacutiphycin

The first total syntheses of the cytotoxic macrolides (+)-acutiphycin (1) and (+)-trans-20,21-didehydroacutiphycin (2) have been achieved. An acyclic stereocontrol strategy was employed to establish the configurations at C(5), C(10), and C(13) as well as the E geometry of the C(8,9)-trisubstituted olefin. Importantly, the natural source of 1 and 2, the blue-green alga Osillatoria acutissima, no longer produces these metabolites.