172269-36-2

Upstream product

• 131685-53-5 (S)-4-benzyl-3-propionyl-2-oxazolidinone 
• 160238-46-0 (2R)-3-(4-methoxybenzyloxy)-2-methyl-1-propanal 
• 212051-35-9 (R)-methyl 3-((4-methoxybenzyl)oxy)-2-methylpropanoate 
• 160238-45-9 (2S)-3-(4-methoxybenzyloxy)-2-methyl-1-propanol 
• 89238-99-3 O-(4-methoxybenzyl)-trichloroacetimidate 

Downstream Products

• 172269-19-1 (2S,3R,4R)-3-Hydroxy-5-(4-methoxy-benzyloxy)-2,4-dimethyl-pentanoic acid methoxy-methyl-amide 
• 1016262-03-5 (S)-3-((2S,3R,4R)-5-(4-methoxybenzyloxy)-3-((3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluorodecyl)diisopropylsilyloxy)-2,4-dimethylpentanoyl)-4-benzyloxazolidin-2-one 
• 1040727-24-9 (1S,3R,4R,5S)-3-((R)-1-{(4R,5R,6S)-6-[(S)-1-(benzyloxy)propano-2-yl]-2,2,5-trimethyl-1,3-dioxan-4-yl}ethyl)-1,4-dimethyl-2,8-dioxabicyclo[3.2.1]octane 
• 208984-65-0 C₆₄H₁₁₈O₈Si₄ 
• 208984-61-6 C₆₃H₁₂₀O₈SSi₄ 
• 208984-62-7 C₆₃H₁₂₂O₈SSi₄ 
• 208984-47-8 (2R,4R,5R)-4-[(Z)-(1S,2S,3R,7R,8S,9R)-2,8-Bis-(tert-butyl-dimethyl-silanyloxy)-10-(4-methoxy-benzyloxy)-1,3,5,7,9-pentamethyl-dec-5-enyl]-2-(4-methoxy-phenyl)-5-methyl-[1,3]dioxane 
• 208984-29-6 (S)-4-Benzyl-3-{(2S,3R,4S)-3-(tert-butyl-dimethyl-silanyloxy)-4-[(2R,4R,5R)-2-(4-methoxy-phenyl)-5-methyl-[1,3]dioxan-4-yl]-2-methyl-pentanoyl}-oxazolidin-2-one 
• 208984-48-9 (Z)-(2R,3S,4R,8R,9S,10S)-3,9-Bis-(tert-butyl-dimethyl-silanyloxy)-10-[(2R,4R,5R)-2-(4-methoxy-phenyl)-5-methyl-[1,3]dioxan-4-yl]-2,4,6,8-tetramethyl-undec-5-en-1-ol 
• 208984-49-0 (2R,4R,5R)-4-[(Z)-(1S,2S,3R,7R,8S,9S)-2,8-Bis-(tert-butyl-dimethyl-silanyloxy)-10-iodo-1,3,5,7,9-pentamethyl-dec-5-enyl]-2-(4-methoxy-phenyl)-5-methyl-[1,3]dioxane 
• 172269-20-4 (S)-4-Benzyl-3-{(2S,3R,4R)-3-hydroxy-4-[(2R,4R,5R)-2-(4-methoxy-phenyl)-5-methyl-[1,3]dioxan-4-yl]-2-methyl-pentanoyl}-oxazolidin-2-one 

Relevant academic research and scientific papers

Synthesis of the C4-C17 fragment of saliniketals a and b

A highly stereoselective synthesis of the C4-C17 fragment of saliniketals A and B was completed. The key steps in this synthesis included a syn-aldol reaction mediated by a boron enolate and a double diastereodifferentiating aldol reaction mediated by a titanium enolate. Moreover, a substrate-controlled Grignard reaction, an intramolecular Wacker-type cyclization and a Seyferth-Gilbert homologation provided the C4-C17 fragment of saliniketals A and B in 16 steps and with a 7 % overall yield. Copyright

Confirmation of the stereostructure of (+)-cytostatin by fluorous mixture synthesis of four candidate stereoisomers

Mix and match: Four closely related candidate isomers for cytostatin have been synthesized by using the technique of fluorous mixture synthesis. Comparison of NMR, thin-layer chromatography, and optical rotation data enabled the three isomers that were not cytostatin to be identified. Thus, by a process of elimination (disproof), the isomer corresponding to cytostatin was determined, and the 4S,5S,6S,9S,10S,11S configuration confirmed. (Chemical Equation Presented).