17228-87-4Relevant academic research and scientific papers
Efficient hydrogenation of sterically hindered olefins with borane-methyl sulfide complex
Rathore,Weigand,Kochi
, p. 5246 - 5256 (2007/10/03)
Sterically hindered olefins are efficiently reduced to the corresponding alkanes by the boranemethyl sulfide (BMS) complex at room temperature (or below) in dichloromethane containing a mild one-electron oxidant (such as an aromatic cation radical) or by the passage of an anodic current. In an alternative procedure, the hydrogenation of the same (electron-rich) olefins with the BMS complex (in the absence of a one-electron oxidant) is also carried out in the presence of a strong Bronsted acid (such as HBF4). In the oxidative activation, olefin cation radicals are the first observable intermediates, and separate experiments (including transient electrochemistry) confirm the facile reduction of the olefin cation radical by borane to produce the corresponding alkane. The direct protonation of olefins produces carbocationic intermediates which are also efficiently reduced by borane to the corresponding alkanes. The intermediacy of both olefin cation radicals and carbocations in the hydrogenation procedure with borane is discussed.
Anti-cancer agents and processes for their preparation
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, (2008/06/13)
Compounds of the formula STR1 wherein R1 and R2 are either two hydrogen atoms or together form a methylene group, and each X is a bromo, iodo or tosyloxy group and the dotted bonds indicate that the central linkage is attached to the
