172291-17-7Relevant academic research and scientific papers
Glycan-specific metabolic oligosaccharide engineering of C7-substituted sialic acids
Moeller, Heinz,Boehrsch, Verena,Bentrop, Joachim,Bender, Judith,Hinderlich, Stephan,Hackenberger, Christian P. R.
, p. 5986 - 5990 (2012)
A new sialic acid in the house! A biosynthetic approach gives access to previously inaccessible C7 modifications of sialic acids in living cells. Metabolic incorporation of synthetically derived N-acetyl-4-azido-4- deoxymannosamine (see scheme) into glycans of mammalian cells and zebrafish larvae preserves the bioorthogonal functionality of its azido group for subsequent labeling with biophysical probes. Copyright
