172294-75-6Relevant academic research and scientific papers
P2X4 RECEPTOR MODULATING COMPOUNDS
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Paragraph 00245, (2015/06/25)
Provided herein are P2X4 receptor modulating compounds, methods of their synthesis, pharmaceutical compositions comprising the compounds, and methods of their use. The compounds provided herein are useful for the treatment, prevention, and/or management of various disorders, including but not limited to, chronic pain, neuropathy, inflammatory diseases and central nervous system disorders.
Selective chemical rescue of a thyroid-hormone-receptor mutant, TRβ(H435Y), identified in pituitary carcinoma and resistance to thyroid hormone
Hassan, A. Quamrul,Koh, John T.
supporting information; experimental part, p. 7280 - 7283 (2009/04/20)
(Figure Presented) Ligand to the rescue! Thyroid hormone receptor (TR) plays a critical role in development and homeostasis. The mutant TRβ(H435Y) was identified in both cancer and resistance to thyroid hormone. A designed synthetic ligand recovered the cellular reporter-gene activity of TRβ(H435Y) with a 5850-fold improvement in selectivity for the mutant relative to that of the natural hormone T3 (shown in a modeled structure with TRβ-(H435Y)).
