172298-83-8

Upstream product

• 1670-14-0 benzamidine monohydrochloride 
• 172298-73-6 tert-butyl (2S)-N-tert-butoxycarbonyl-4-methoxymethylenepyroglutamate 
• 91229-91-3 tert-butyl (S)-N-tert-butoxycarbonylpyroglutamate 
• 151121-34-5 di-tert-butyl (2S,4E)-4-[(dimethylamino)methylidene]-5-oxopyrrolidine-1,2-dicarboxylate 

Relevant academic research and scientific papers

Synthesis of glutamate agonists and antagonists by a ring switching strategy

Our ring switching strategy for synthesis of compounds with structural features consistent with activity at glutamate receptors has been modified to prepare L-alanine derivatives substituted at the β-carbon atom with six-membered heteroaromatic rings. The pyrimidinone (11, R = R1 = R2 = H) has been shown to be a glutamate agonist and the compound (13) to be an antagonist.

Synthesis of agonists and antagonists for central glutamate receptors by a novel 'ring switching' strategy

A novel and versatile ring switching strategy has been developed for the synthesis of compounds with structural features consistent with activity at glutamate receptors. A variety of homochiral L-alanine derivatives substituted at the β-carbon atom with planar five and six-membered heteroaromatic rings have been prepared in a one- or two-pot reaction using this strategy and some of the products have been shown to have biological activity at central glutamate receptors.