172349-26-7

Basic information

• Product Name: C₂₆H₃₂N₄O₅
• Synonyms: C₂₆H₃₂N₄O₅
• CAS NO: 172349-26-7
• Molecular Weight: 480.564
• Mol File: 172349-26-7.mol

Chemical Properties

• CAS DataBase Reference: C₂₆H₃₂N₄O₅(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₆H₃₂N₄O₅(172349-26-7)
• EPA Substance Registry System: C₂₆H₃₂N₄O₅(172349-26-7)

Safety Data

• Hazardous Substances Data: 172349-26-7(Hazardous Substances Data)

Upstream product

• 15761-39-4 1-(tert-butoxycarbonyl)-L-proline 

Downstream Products

• 187752-79-0 C₂₁H₂₄N₄O₃ 
• 1374963-02-6 C₃₃H₃₉N₅O₆S 
• 1374962-30-7 N-benzenesulfonyl-D-leucyl-L-prolyl-{[4-(N-benzyloxycarbonyl)amidinophenyl]methyl} amide 
• 1374963-04-8 C₃₅H₄₁N₅O₅ 
• 1374963-11-7 C₃₃H₃₉N₅O₆S 
• 1374962-40-9 C₂₅H₃₃N₅O₄S*ClH 
• 1374963-27-5 N-dimethylaminosulfonyl-D-leucyl-L-prolyl-{[4-(N-benzyloxycarbonyl)amidinophenyl]methyl}amide 
• 1374963-28-6 C₂₈H₃₇N₅O₆S 
• 1374963-29-7 C₂₉H₃₉N₅O₆S 
• 1374963-30-0 C₃₀H₃₉N₅O₆S 
• 1215172-80-7 N-(tert-butyloxycarbonyl)-D-leucyl-L-prolyl-{4-[(N-(benzyloxy)carbonyl)carbamimidoyl]benzyl}amide 

Relevant articles and documents

Structure-based organic synthesis of unnatural aeruginosin hybrids as potent inhibitors of thrombin

Based on X-ray crystallographic data of complexes of chlorodysinosin A with the enzyme thrombin, a series of analogs were synthesized varying the nature of the P1, P2, and P3 pharmacophoric sites and the central octahydroindole carboxyamide core. In general, introduction of a hydrophobic substituent on the d-leucine amide residue dramatically improved the inhibition of the enzyme. This is rationalized based on a better fit of the P3 subunit in the hydrophobic S3 enzyme site. Single digit nanomolar inhibition expressed as IC50 was observed for several analogs.

PROLINAMIDE DERIVATIVE AS THROMBIN INHIBITOR, PREPARATION METHOD AND APPLICATION THEREOF

Provided are a compound of formula (I), pharmaceutically acceptable salts thereof, preparation methods and applications thereof for inhibiting thrombin, and applications in the treatment and prevention of thrombin-mediated and thrombin-related diseases.