172349-26-7

Basic information

• Product Name: C₂₆H₃₂N₄O₅
• Synonyms: C₂₆H₃₂N₄O₅
• CAS NO: 172349-26-7
• Molecular Weight: 480.564
• Mol File: 172349-26-7.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: C₂₆H₃₂N₄O₅(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₆H₃₂N₄O₅(172349-26-7)
• EPA Substance Registry System: C₂₆H₃₂N₄O₅(172349-26-7)

Safety Data

• Hazardous Substances Data: 172349-26-7(Hazardous Substances Data)

Upstream product

• 15761-39-4 1-(tert-butoxycarbonyl)-L-proline 

Downstream Products

• 187752-79-0 C₂₁H₂₄N₄O₃ 
• 1374963-02-6 C₃₃H₃₉N₅O₆S 
• 1374962-30-7 N-benzenesulfonyl-D-leucyl-L-prolyl-{[4-(N-benzyloxycarbonyl)amidinophenyl]methyl} amide 
• 1374963-04-8 C₃₅H₄₁N₅O₅ 
• 1374963-11-7 C₃₃H₃₉N₅O₆S 
• 1374962-40-9 C₂₅H₃₃N₅O₄S*ClH 
• 1374963-27-5 N-dimethylaminosulfonyl-D-leucyl-L-prolyl-{[4-(N-benzyloxycarbonyl)amidinophenyl]methyl}amide 
• 1374963-28-6 C₂₈H₃₇N₅O₆S 
• 1374963-29-7 C₂₉H₃₉N₅O₆S 
• 1374963-30-0 C₃₀H₃₉N₅O₆S 
• 1215172-80-7 N-(tert-butyloxycarbonyl)-D-leucyl-L-prolyl-{4-[(N-(benzyloxy)carbonyl)carbamimidoyl]benzyl}amide 

Relevant articles and documents

Structure-based organic synthesis of unnatural aeruginosin hybrids as potent inhibitors of thrombin

Based on X-ray crystallographic data of complexes of chlorodysinosin A with the enzyme thrombin, a series of analogs were synthesized varying the nature of the P1, P2, and P3 pharmacophoric sites and the central octahydroindole carboxyamide core. In general, introduction of a hydrophobic substituent on the d-leucine amide residue dramatically improved the inhibition of the enzyme. This is rationalized based on a better fit of the P3 subunit in the hydrophobic S3 enzyme site. Single digit nanomolar inhibition expressed as IC50 was observed for several analogs.