172366-38-0

Basic information

• Product Name: 5,7-Difluoro-2-tetralone
• Synonyms: 5,7-DF2T;5,7-DIFLUORO-2-TETRALONE;5,7-DIFLUORO-3,4-DIHYDRO-2H-NAPHTHALEN-1-ONE;5,7-Difluoro-3,4-dihydro-1H-naphthalen-2-one;7-Difluoro-2-tetralone;5,7-Difluoro-3,4-dihydronaphthalen-2(1H)-one
• CAS NO: 172366-38-0
• Molecular Formula: C10H8F2O
• Molecular Weight: 182.17
• Product Categories: pharmacetical
• Mol File: 172366-38-0.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 260.58 °C at 760 mmHg
• Flash Point: 99.41 °C
• Appearance: /
• Density: 1.29 g/cm³
• Vapor Pressure: 0.0121mmHg at 25°C
• Refractive Index: 1.523
• CAS DataBase Reference: 5,7-Difluoro-2-tetralone(CAS DataBase Reference)
• NIST Chemistry Reference: 5,7-Difluoro-2-tetralone(172366-38-0)
• EPA Substance Registry System: 5,7-Difluoro-2-tetralone(172366-38-0)

Safety Data

• Hazardous Substances Data: 172366-38-0(Hazardous Substances Data)

Usage

General Description

5,7-Difluoro-2-tetralone is a chemical compound with the molecular formula C10H6F2O. It is a fluorinated derivative of tetralone, which is a bicyclic aromatic ketone. 5,7-Difluoro-2-tetralone is mainly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. It has been studied for its potential antifungal and antibacterial properties. 5,7-Difluoro-2-tetralone has also been investigated for its potential use in organic electronic materials due to its unique structural and electronic properties. Overall, this compound has potential applications in various industries, including pharmaceuticals and materials science.

InChI:InChI=1/C10H8F2O/c11-7-3-6-4-8(13)1-2-9(6)10(12)5-7/h3,5H,1-2,4H2

Upstream product

• 105184-38-1 3,5-difluorophenyl acetic acid 
• 74-85-1 ethene 
• 157033-24-4 3,5-difluorophenylacetyl chloride 

Downstream Products

• 173996-47-9 (R)-2-amino-5,7-difluoro-1,2,3,4-tetrahydronaphthalene hydrochloride 
• 180914-87-8 (R)-5,7-difluoro-1,2,3,4-tetrahydronaphthalene-2-amine 
• 170151-28-7 (S)-5,7-difluoro-1,2,3,4-tetrahydronaphthalene-2-amine 

Relevant articles and documents

Method for preparing optically pure 5,7-difluoro-1,2,3,4-tetrahydronaphthalene-2-amine and salts thereof

The invention discloses a method for preparing optically pure 5,7-difluoro-1,2,3,4-tetrahydronaphthalene-2-amine as shown in formulas a and b and salts thereof. The method comprises the following steps: (1) reacting 3,5-difluorophenylacetic acid with SOCl2 in the presence of a solvent to generate acyl chloride, and then carrying out Friedel-Crafts reaction on the acyl chloride and ethylene under the action of aluminum trichloride; (2) reacting 5,7-difluoro-3,4-dihydronaphthalene-2(1H)-ketone with amide in an organic solvent under an acid catalysis condition, and performing dehydrating to generate enamine; (3) performing catalytic hydrogenation on enamine in the presence of a chiral catalyst to prepare an optically pure intermediate amide; and (4) hydrolyzing the amide under an acidic or alkaline condition to obtain the optically pure 5,7-difluoro-1,2,3,4-tetrahydronaphthalene-2-amine (a or b) and the form of the salts thereof. The invention provides the method for preparing the optically pure 5,7-difluoro-1,2,3,4-tetrahydronaphthalene-2-amine and salts thereof, which is simple, convenient and easy to industrial production.

METHODS FOR TREATING DEPENDENCE

no abstract published

COMPOUND HAVING TETRAHYDRONAPHTHALENE SKELETON AND LIQUID CRYSTAL COMPOSITION CONTAINING THE SAME

A tetrahydronaphthalene derivative represented by the general formula (I) and a liquid crystal composition containing the same. A compound represented by the general formula (I) shows superior liquid crystallinity and co-solubility with conventional liquid crystal compounds and compositions. Furthermore, addition of such a compound enables the threshold voltage to be significantly reduced with almost no deleterious effect on the responsiveness. In addition, a compound of the present invention can also be easily produced industrially, is colorless, and is chemically stable. Consequently, liquid crystal compositions containing such a compound are extremely useful as liquid crystals, and are particularly suitable for liquid crystal displays requiring a wide operating temperature range, low voltage driving and a high response speed.