172405-24-2Relevant academic research and scientific papers
Novel synthetic routes to PNA monomers and PNA-DNA linker molecules
Breipohl, Gerhard,Will, David W.,Peyman, Anusch,Uhlmann, Eugen
, p. 14671 - 14686 (1997)
Novel methods for the preparation of monomethoxytrityl (Mmt) protected aminoethylglycine building blocks and dimethoxytrityl (Dmt) protected hydroxyethylglycine derivatives useful for the synthesis of polyamide nucleic acids (PNAs) and PNA/DNA chimeras are described. The protecting group strategy employed for PNA monomer synthesis produces easily isolable intermediates, minimizes chromatographic purification, and is suitable for large-scale monomer synthesis.
