17242-88-5

Basic information

• Product Name: 5-fluoro-1-hexopyranosylpyrimidine-2,4(1H,3H)-dione
• CAS NO: 17242-88-5
• Molecular Formula: C₁₀H₁₃FN₂O₇
• Molecular Weight: 292.2178
• Mol File: 17242-88-5.mol
• Article Data: 2

Chemical Properties

• Density: 1.79g/cm³
• Refractive Index: 1.654
• CAS DataBase Reference: 5-fluoro-1-hexopyranosylpyrimidine-2,4(1H,3H)-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 5-fluoro-1-hexopyranosylpyrimidine-2,4(1H,3H)-dione(17242-88-5)
• EPA Substance Registry System: 5-fluoro-1-hexopyranosylpyrimidine-2,4(1H,3H)-dione(17242-88-5)

Safety Data

• Hazardous Substances Data: 17242-88-5(Hazardous Substances Data)

Upstream product

• 604-69-3 β-D-glucose pentaacetate 
• 17242-87-4 (2R,3R,4S,5R,6R)-2-(acetoxymethyl)-6-(5-fluoro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydro-2H-pyran-3,4,5-triyl triacetate 

Relevant articles and documents

Synthesis of 18F labelled nucleoside analogues

Several nucleoside analogues like 1-(β-D-glucopyranosyl)-5-fluorouracil 10, 1-(β-D-galactopyranosyl)-5-fluorouracil 11 and 1-(2-deoxy-β-D-glucopyranosyl)- 5-fluorouracil 12 have been synthesized. From the corresponding 1-(2',3',4',6'-tetra-O-acetyl-β-D-glycopyranosyl)-uracil 4, 5 and 6, the 18F labelled compounds 16, 17 and 18 have been prepared via the intermediates 13, 14 and 15 in acetic acid using [18F]F2 and acidic deacetylating procedures. The 18F labelled derivatives could be obtained, following preparative chromatography, in high purity and in yields of about 3.108 Bq - 5.7·108 Bq (18% - 34% related to the trapped radioactivity, not corrected for decay) for their in-vine evaluation and for in-vivo studies with PET.