172426-88-9

Basic information

• Product Name: 3-Quinolinecarboxylic acid, 7-aMino-1-cyclopropyl-6-fluoro-1,4-dihydro-8-Methoxy-4-oxo-
• Synonyms: 3-Quinolinecarboxylic acid, 7-aMino-1-cyclopropyl-6-fluoro-1,4-dihydro-8-Methoxy-4-oxo-;7-AMino-1-cyclopropyl-6-fluoro-1,4-dihydro-8-Methoxy-4-oxo-3-quinolinecarboxylic Acid;Moxifloxacin Impurity 1;Moxifloxacin Impurity 28;Moxifloxacin Impurity 18;Moxifloxacin Impurity T
• CAS NO: 172426-88-9
• Molecular Formula: C14H13FN2O4
• Molecular Weight: 292.2624232
• Product Categories: Heterocycles, Impurities, Pharmaceuticals, Intermediates & Fine Chemicals
• Mol File: 172426-88-9.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 516.3±50.0 °C(Predicted)
• Appearance: /
• Density: 1.582±0.06 g/cm3(Predicted)
• Storage Temp.: Refrigerator
• Solubility: DMSO (Slightly), Methanol (Slightly Heated)
• PKA: 6.42±0.50(Predicted)
• CAS DataBase Reference: 3-Quinolinecarboxylic acid, 7-aMino-1-cyclopropyl-6-fluoro-1,4-dihydro-8-Methoxy-4-oxo-(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Quinolinecarboxylic acid, 7-aMino-1-cyclopropyl-6-fluoro-1,4-dihydro-8-Methoxy-4-oxo-(172426-88-9)
• EPA Substance Registry System: 3-Quinolinecarboxylic acid, 7-aMino-1-cyclopropyl-6-fluoro-1,4-dihydro-8-Methoxy-4-oxo-(172426-88-9)

Safety Data

• Hazardous Substances Data: 172426-88-9(Hazardous Substances Data)

Usage

Uses

7-Amino-1-cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid is an impurity of Moxifloxacin (M745000), a fluorinated quinolone antibacterial agent.

Upstream product

• 139693-52-0 1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinoline carboxylic acid-O³,O⁴(bis(acyloxy-O)) borate 
• 496919-99-4 1-cyclopropyl-6,7-difluoro-8-methoxy-4-oxo-1,4-dihydro-3-quinoline-carboxylic acid O₃,O₄-bis(propyloxy-O)borate 
• 1123923-23-8 1-cyclopropyl-7-amino-6-fluoro-8-methoxy-1,4-dihydro-4-oxo-3-quinolinecarboxylate ethyl ester 
• 112811-71-9 ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate 
• 7722-64-7 potassium permanganate 
• 151096-09-2 moxifloxacin 

Relevant articles and documents

Permanganate oxidative products of moxifloxacin, a fluoroquinolone drug: A mechanistic approach

The kinetics of oxidation of moxifloxacin (MOX) was studied spectrophotometrically by a well-recognized analytical reagent, permanganate (Mn(VII), in aqueous alkaline medium at a constant ionic strength. The reaction was first order in [Mn(VII)] and less than unit order both in [MOX] and [alkali]. Retarding effect on rate of reaction was observed with an increase in ionic strength. The effect of dielectric constant of the medium was also studied. The multiple m/z values of ESI-MS spectra prove the existence of various oxidative products of MOX. The main product was identified as 1-cyclopropyl-6-fluoro-1,4-dihydro-7-(octahydro-2-oxopyrrolo[3,4-b] pyridin-6-yl)-8-methoxy-4-oxoquinoline-3-carboxylic acid. The other three oxidative products from MOX in the present study are similar to the oxidative products of other fluoroquinolones oxidations. However, the abnormally high values of m/z could be assigned to the permanganate complexes of the products, which are unusual in the non-metallic oxidation of MOX. A composite mechanism involving the monohydropermangante as the reactive species of the oxidant has been proposed. Activation parameters and thermodynamic parameters are calculated and the reaction constants involved in the different steps of the mechanisms are calculated.

A hydrochloric acid Moxifloxacin impurity of the preparation method, detection method and use thereof (by machine translation)

The invention discloses a hydrochloric acid moxifolxacin light degradation of the impurity of the preparation method, detection method and its hydrochloric acid Moxifloxacin relevant substance inspection when the use as the impurity of the reference substance. Through the preparation of the compound, to hydrochloric acid Moxifloxacin related substance analysis of a reference substance, thereby improving the quality standards moxifolxacin hydrochloride, hydrochloric acid moxifolxacin security administration provides important guidance significance. (by machine translation)