17245-47-5

Upstream product

• 882-33-7 diphenyldisulfane 
• 957-75-5 aBrUra 

Downstream Products

• 24704-26-5 (3aS)-3c-benzoyloxy-2t-benzoyloxymethyl-(3ar,9ac)-2,3,3a,9a-tetrahydro-furo[2',3':4,5]oxazolo[3,2-c]pyrimidine-6,8-dione 
• 24710-89-2 (3aS)-3c-benzoyloxy-2t-benzoyloxymethyl-6-thioxo-(3ar,9ac)-2,3,3a,6,7,9a-hexahydro-furo[2',3':4,5]oxazolo[3,2-c]pyrimidin-8-one 
• 110261-83-1 (2R,3R,3aS,9aR)-5-Chloro-3-hydroxy-2-trityloxymethyl-2,3,3a,9a-tetrahydro-furo[2',3':4,5]oxazolo[3,2-c]pyrimidine-6,8-dione 
• 42890-72-2 5'-O-monomethoxytrityl-6,2'-O-cyclouridine 

Relevant academic research and scientific papers

Synthesis of 5-arylthiouridines via electrophilic substitution of 5- bromouridines with diaryl disulfides

Novel synthetic method of 5-arylthiouridine derivatives is described. Treatment of 5-bromo-2',3'-O-isopropylideneuridine (1a) with diaryl disulfides in the presence of sodium hydride at ambient temperature gave the 5-arylthiouridines (2) in moderate yields. The present method is devised by virtue of a combination of efficient participation of the 5'-hydroxy group onto the uracil ring and the electrophilic nature of diaryl disulfide, which was applied to the synthesis of 5-arylthio-1-β-D-arabinofuranosyluracils (8).