172477-12-2Relevant academic research and scientific papers
A practical preparation of enantiomerically pure (R)- and (S)-2-bromohexadecanoic acids
Guo, Jinsong,Knapp, David W.,Boegeman, Stephanie
, p. 4105 - 4111 (2000)
The efficient preparation of enantiomerically pure (R)- and (S)-2-bromohexadecanoic acids with e.e.>95% through resolution with the use of a recoverable chiral auxiliary is described. The procedure involves three reactions: Steglich esterification, DIBAL reduction, and Sharpless oxidation. The assessment of the enantiomeric purity is based on NMR analysis by using (1R,2R)-(+)-diphenylethane-1,2-diamine as a chiral solvating agent. Copyright (C) 2000 Elsevier Science Ltd.
