172484-96-7Relevant academic research and scientific papers
Chemoenzymatic synthesis of the morphine skeleton via radical cyclization and a C10-C11 closure
Butora, Gabor,Hudlicky, Tomas,Fearnley, Stephen P.,Gum, Andrew G.,Stabile, Michele R.,Abboud, Khalil
, p. 8155 - 8158 (2007/10/03)
A short synthesis of a morphinan skeleton has been accomplished. The key steps involve enzymatic dihydroxylation of β-bromoethyl benzene, vinyl and aryl radical cyclizations, and Friedel-Crafts closure of an aziridinium ion or an acid-catalyzed closure of an aldehyde to form the C10-C11 bond.
