172505-78-1 Usage
Chemical structure
The compound has a complex structure that includes a thiazole ring, a thiourea functional group, a nitrophenyl group, and an ethyl chain.
Biological activities
Thioureas are known for their diverse biological activities, which may include antimicrobial, antiviral, and antitumor properties.
Thiazole ring
The presence of the thiazole ring suggests potential biological activity related to this structural motif.
Potential applications
The compound may have potential applications in the development of pharmaceuticals or agrochemicals.
Further research
Further research would be needed to fully understand the properties and potential uses of this compound.
Nitro group
The presence of a nitro group (-NO2) in the compound may contribute to its reactivity and potential applications.
Ethyl chain
The ethyl chain (-CH2CH3) in the compound may influence its solubility and other physical properties.
Chemical reactivity
The compound may exhibit reactivity due to the presence of the nitro group and the thiourea functional group.
Molecular weight
The molecular weight of the compound is approximately 238.28 g/mol.
Structural isomers
The compound may have structural isomers, which could have different properties and applications.
Stability
The stability of the compound under various conditions (e.g., temperature, pH, etc.) would need to be investigated.
Synthesis
The synthesis of the compound may involve multiple steps, including the formation of the thiazole ring and the attachment of the nitrophenyl and ethyl groups.
Purity
The purity of the synthesized compound would need to be confirmed, as impurities could affect its properties and potential applications.
Characterization
Techniques such as NMR, IR, and mass spectrometry would be used to characterize the compound and confirm its structure.
Check Digit Verification of cas no
The CAS Registry Mumber 172505-78-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,7,2,5,0 and 5 respectively; the second part has 2 digits, 7 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 172505-78:
(8*1)+(7*7)+(6*2)+(5*5)+(4*0)+(3*5)+(2*7)+(1*8)=131
131 % 10 = 1
So 172505-78-1 is a valid CAS Registry Number.
172505-78-1Relevant articles and documents
Phenethylthiazolethiourea (PETT) compounds, a new class of HIV-1 reverse transcriptase inhibitors. 1. Synthesis and basic structure-activity relationship studies of PETT analogs
Bell,Cantrell,Hogberg,Jaskunas,Johansson,Jordan,Kinnick,Lind,Morin Jr.,Noreen,Oberg,Palkowitz,Parrish,Pranc,Sahlberg,Ternansky,Vasileff,Vrang,West,et al.
, p. 4929 - 4936 (2007/10/03)
A novel series of potent specific HIV-1 inhibitory compounds is described. The lead compound in the series, N-(2-phenethyl)-N'-(2-thiazolyl)thiourea (1), inhibits HIV-1 RT using rCdG as the template with an IC50 of 0.9 μM. In MT-4 cells, compound 1 inhibits HIV-1 with an ED50 of 1.3 μM. The 50% cytotoxic dose in cell culture is >380 μM. The chemical structure-activity relationship (SAR) was developed by notionally dividing the lead compound in four quadrants. The SAR strategy had two phases. The first phase involved optimization of antiviral activity through independent variation of quadrants 1-4. The second phase involved the preparation of hybrid structures combining the best of these substituents. Further SAR studies and pharmacokinetic considerations led to the identification of N-(2-pyridyl)-N'-(5-bromo-2- pyridyl)-thiourea (62; LY300046 · HCl) as a candidate for clinical evaluation. LY300046 · HCl inhibits HIV-1 RT with an IC50 of 15 nM and in cell culture has an ED50 of 20 nM.
