172508-64-4Relevant academic research and scientific papers
A facile synthesis of 5-substituted 2-furyl-, 2-thienyl- and 2- pyrrolylacetates by cyclodehydration of γ-functionalized α,β-unsaturated ketones
Kawano, Tomikazu,Ogawa, Toni,Md. Islam, Saiful,Ueda, Ikuo
, p. 1279 - 1295 (2007/10/03)
Synthesis of 5-substituted 2-furyl-, 2-thienyl- and 2-pyrrolylacetates is achieved by acid-catalyzed cyclodehydration of γ-hydroxy (γ-acetylthio and γ-amino)-α,β-unsaturated ketones generated from ethyl 6-substituted 3- ethoxy-6-hydroxy-(6-acetylthio and 6-amino)hexa-2,4-dienoates which are easily accessible from α-functionalized carbonyl compounds and Wittig reagents.
A facile synthesis of 5-substituted 2-furylacetates via 6-hydroxy-3-oxo-4-hexenoates
Kawano, Tomikazu,Ogawa, Toru,Islam, Saiful Md.,Ueda, Ikuo
, p. 7685 - 7688 (2007/10/02)
6-Substituted 3-ethoxy-6-hydroxy-2,4-hexadenoates (4) which were prepared by reaction of ethyl (4E)-3-ethoxy-5-formyl-2,4-pentadienoate (3a) with nucleophiles or sodium borohydride reduction of 6-substituted 3-ethoxy-6-oxo-2,4-hexadenoates (3b-e) have been converted in very good yields into 5-substituted 2-furylacetates (5) by treating with 47% HBr in THF.
