172542-57-3Relevant articles and documents
Biarylcarboxamide inhibitors of phosphodiesterase IV and tumor necrosis factor-
Chambers,Marfat,Cheng,Cohan,Damon,Duplantier,Hibbs,Jenkinson,Johnson,Kraus,Pettipher,Salter,Shirley,Umland
, p. 739 - 744 (2007/10/03)
Tumor necrosis factor-α (TNF-α) has been implicated as a key mediator in the progression of rheumatoid arthritis. Inhibitors of phosphodiesterase IV (PDE IV) have been shown to inhibit the production of TNF-α by elevating intracellular levels of cyclic adenosine monophosphate (cAMP). Our efforts in a series of biarylcarboxamides have led to the identification of 8j (CP-353,164) as a potent inhibitor of PDE IV and TNF-α production.