17259-82-4Relevant academic research and scientific papers
A new general approach to 4-substituted-3-halo-2-quinolones
Zhao, Shuai,He, Yan-hong,Wu, Di,Guan, Zhi
experimental part, p. 597 - 605 (2010/06/21)
A general procedure for the preparation of 4-substituted-3-halo-2-quinolones (halo = F, Cl, Br) utilizing 2-halo diethylphosphonoacetic acids (halo = F, Cl, Br) and o-aminophenylketones as the starting materials is described. The title compounds are obtained by an intramolecular Horner-Wadsworth-Emmons olefination of halogen-containing N-acyl-o-aminophenylketones. The transformation process is generally applicable under mild conditions.
