17265-63-3Relevant academic research and scientific papers
Heterocyclic Analogues of Chlorcyclizine with Potent Hypolipidemic Activity
Ashton, Michael J.,Ashford, Alan,Loveless, Anthony H.,Riddell, David,Salmon, John,Stevenson, Gregory V.W.
, p. 1245 - 1253 (2007/10/02)
A series of piperazines was synthesized and their effect of reducing serum cholesterol and triglyceride levels in the rat was evaluated.A systematic exploration of the structure-activity relationships led to the synthesis of (R,S)-(3,5-dimethylisoxazol-4-yl)(4-methylpiperazin-1-yl)methane dihydrochloride (M and B 31426), which had potent activity in lowering serum lipid levels at a daily oral dose of 2 mg/kg and was 100 times more potent than clofibrate.
