17265-94-0Relevant academic research and scientific papers
Protonium-deuterium exchange of substituted pyridines in neutral D2O at elevated temperatures
Werstiuk, Henry Nick,Ju, Chen
, p. 5 - 10 (2007/10/02)
H-D exchange of a series of pyridines 1-15, 10H-pyridinobenzothiazine (16), phenothiazine (17), and aniline has been carried out in neutral D2O at elevated temperatures.The substrates undergo selective exchange and are generally isolated in good yield.Cyanopyridines 4, 5 and 6 hydrolyze readily in D2O at elevated temperatures, and the resultant carboxylic acids decarboxylate.This reaction provides a convenient one-step route to selectively labelled pyridines.Possible mechanisms of exchange are presented.Key words: protium-deuterium exchange, substituted pyridines, temperature effect
