172657-46-4Relevant academic research and scientific papers
Simple methodology for syntheses of porphyrins possessing multiple peripheral substituents with an element of symmetry
Nguyen, Liem T.,Senge, Mathias O.,Smith, Kevin M.
, p. 998 - 1003 (2007/10/03)
New methodology was developed for synthesis of regiochemically pure porphyrins with D2h symmetry (e.g. 9) via tetramerization reactions involving two different pyrroles. The two pyrrole components were a 2,5-diunsubstituted pyrrole (e.g. 11) and a 2,5-bis[(N,N-dimethylamino)methyl]pyrrole (e.g. 10), the latter being formed from a 2,5-di-unsubstituted pyrrole by treatment with excess Eschenmoser's reagent (N,N-dimethylmethyleneammonium iodide). A bis-butanoporphyrin 16 was transformed into the corresponding opp-bis-benzoporphyrin 17 by treatment with DDQ. The synthetic method was further extended to allow the synthesis of more unsymmetrical porphyrins, with C2v, symmetry (e.g. 32), by reacting a tripyrrane (e.g. 27) with a 2,5-bis[(N,N-dimethylamino)-methyl]pyrrole (e.g. 18). The structures and substituent arrays in both type of porphyrins were confirmed by single-crystal X-ray crystallography.
Synthesis of a novel bis-gluco-crown ether derivative
Kanakamma,Mani,Nair
, p. 3777 - 3787 (2007/10/03)
An efficient synthesis of a novel bis-gluco-22-crown-6-derivative 1 from allyl-α-D-glucopyranoside is described.
