17269-79-3

Basic information

• Product Name: 4-allyl-2-bromo-phenol
• Synonyms: 4-allyl-2-bromo-phenol
• CAS NO: 17269-79-3
• Molecular Weight: 213.074
• Mol File: 17269-79-3.mol

Chemical Properties

• CAS DataBase Reference: 4-allyl-2-bromo-phenol(CAS DataBase Reference)
• NIST Chemistry Reference: 4-allyl-2-bromo-phenol(17269-79-3)
• EPA Substance Registry System: 4-allyl-2-bromo-phenol(17269-79-3)

Safety Data

• Hazardous Substances Data: 17269-79-3(Hazardous Substances Data)

Upstream product

• 140-67-0 Estragole 
• 501-92-8 4-(prop-2-enyl)phenol 

Downstream Products

• 68592-15-4 methylhonokiol 

Relevant articles and documents

Expedient synthesis of 4-O-methylhonokiol via Suzuki-Miyaura cross-coupling

Concise and practical synthesis of 4-O-methylhonokiol was achieved in 34% overall yield. The key features of our synthesis include chemoselective ortho-mono bromination of phenol as well as biaryl formation via Suzuki-Miyaura cross-coupling, in which bromophenol was reacted with potassium aryltrifluoroborate using Pd(OAc)2 and RuPhos under microwave conditions.

Magnolol derivative, honokiol derivative, hydrochloride of honokiol derivative, preparation method and application

The invention discloses a magnolol derivative, a honokiol derivative, hydrochloride of honokiol derivative, a preparation method and application of the honokiol derivative and the hydrochloride. The magnolol derivative, the honokiol derivative and the hydrochloride of the honokiol derivative have the structure shown in the following formula (I), and by applying the technical scheme provided by theinvention, the magnolol derivative, the honokiol derivative and the hydrochloride of the honokiol derivative are modularly prepared by utilizing a chemical synthesis method, namely a C14 atom markerand a D atom marker, the two compounds can be used for drug metabolism research of magnolol derivatives, honokiol derivatives and hydrochloride thereof. The problems caused by low drug recovery rate in the traditional drug metabolism experiment can be well solved by using the C14 marker, and the processes related to in-vivo absorption, distribution, metabolism and excretion of the drug can be conveniently clarified.

Method for Synthesizing 4-O-Methylhonokiol

The present invention refers to a the active compounds useful 4-O-methylhonokiol-chemical method synthesis of relates to a preparation. Of the existing method according to the present invention extracted from natural 4-O the method obtaining-methylhonokiol produce highly pure crude high yield by a unidirectional photocoupler the product may be-methylhonokiol 4-O unit is off.

In vitro growth inhibition of human cancer cells by novel honokiol analogs

Honokiol possesses many pharmacological activities including anti-cancer properties. Here in, we designed and synthesized honokiol analogs that block major honokiol metabolic pathway which may enhance their effectiveness. We studied their cytotoxicity in human cancer cells and evaluated possible mechanism of cell cycle arrest. Two analogs, namely 2 and 4, showed much higher growth inhibitory activity in A549 human lung cancer cells and significant increase of cell population in the G0-G1 phase. Further elucidation of the inhibition mechanism on cell cycle showed that analogs 2 and 4 inhibit both CDK1 and cyclin B1 protien levels in A549 cells.