172691-22-4

Upstream product

• 172691-26-8 (S)-3-[(2R,3R)-3-(4-Bromo-benzyloxymethyl)-oxiranyl]-3-(tert-butyl-diphenyl-silanyloxy)-propionic acid tert-butyl ester 
• 58479-61-1 tert-butylchlorodiphenylsilane 
• 141277-18-1 (3S,4S,5R)-tert-butyl <6-(p-bromobenzyloxy)-4,5-epoxy-3-hydroxy>hexanoate 

Downstream Products

• 172691-48-4 Benzoic acid (R)-2-(4-bromo-benzyloxy)-1-[(2S,3S)-3-(tert-butyl-diphenyl-silanyloxy)-5-oxo-tetrahydro-furan-2-yl]-ethyl ester 
• 172293-72-0 (4S,5R,1'S)-5-<2'-<(4-Bromobenzyl)oxy>-1'-hydroxyethyl>-4-hydroxy-2-oxo-1-oxacyclopentane 

Relevant academic research and scientific papers

Synthesis of 2'-deoxynucleosides substituted in C-5'

Stereocontrolled lactonisation of γ,δ-epoxy β-hydroxyesters provides, after reduction, 2-deoxysugars in pyrano or furano form. After appropriate protection of the hydroxyl functions, these sugars can be converted to various 2'-deoxynucleosides with different configuration of the sugar moiety and an extra functionalisation at C-5.