172733-32-3 Usage
Molecular structure
1H-Indole-3-acetamide, 2-ethyl-5-hydroxy-α-oxo-1-(phenylmethyl)is a complex organic compound with a combination of different functional groups and a heterocyclic indole ring.
Indole derivative
The compound is derived from the base structure of indole, which is a naturally occurring heterocyclic organic compound found in plants and some animals.
Functional groups
The specific chemical contains an ethyl group, hydroxyl group, alpha-keto group, and a phenylmethyl group, which contribute to its potential reactivity and applications.
Ethyl group
A two-carbon group derived from ethane, adding complexity to the molecular structure.
Hydroxyl group
An oxygen atom bonded to a hydrogen atom, which can form hydrogen bonds and participate in various chemical reactions.
Alpha-keto group
A carbonyl group (C=O) bonded to a carbon atom, which is adjacent to the amino group in the indole ring, providing additional reactivity and possibilities for further chemical modification.
Phenylmethyl group
A benzene ring bonded to a methyl group (CH3), which contributes to the compound's lipophilicity and may influence its biological activity.
Potential applications
Due to its unique structure and the presence of various functional groups, this chemical may be useful in medicinal chemistry and pharmaceutical research.
Biological activities
The compound may exhibit various biological activities, such as binding to specific receptors or enzymes, which could be harnessed for therapeutic purposes.
Drug synthesis
The compound could serve as a building block for the development of new drugs, either as a precursor or as a template for designing more complex molecules.
Need for further research
Despite its potential applications, more research and investigation are needed to fully understand the properties and implications of 1H-Indole-3-acetamide, 2-ethyl-5-hydroxy-α-oxo-1-(phenylmethyl)-. This includes studying its stability, reactivity, and potential interactions with biological systems.
Check Digit Verification of cas no
The CAS Registry Mumber 172733-32-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,7,2,7,3 and 3 respectively; the second part has 2 digits, 3 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 172733-32:
(8*1)+(7*7)+(6*2)+(5*7)+(4*3)+(3*3)+(2*3)+(1*2)=133
133 % 10 = 3
So 172733-32-3 is a valid CAS Registry Number.
172733-32-3Relevant academic research and scientific papers
Indole inhibitors of human nonpancreatic secretory phospholipase A2. 3. Indole-3-glyoxamides
Draheim, Susan E.,Bach, Nicholas J.,Dillard, Robert D.,Berry, Dennis R.,Carlson, Donald G.,Chirgadze, Nickolay Y.,Clawson, David K.,Hartley, Lawrence W.,Johnson, Lea M.,Jones, Noel D.,McKinney, Emma R.,Mihelich, Edward D.,Olkowski, Jennifer L.,Schevitz, Richard W.,Smith, Amy C.,Snyder, David W.,Sommers, Cynthia D.,Wery, Jean-Pierre
, p. 5159 - 5175 (2007/10/03)
The preceding papers of this series detail the development of functionalized indole-3-acetamides as inhibitors of hnps-PLA2. We describe here the extension of the structure-activity relationship to include a series of indole-3-glyoxamide derivatives. Functionalized indole-3-glyoxamides with an acidic substituent appended to the 4- or 5-position of the indole ring were prepared and tested as inhibitors of hnps-PLA2. It was found that the indole-3-glyoxamides with a 4-oxyacetic acid substituent had optimal inhibitory activity. These inhibitors exhibited an improvement in potency over the best of the indole-3-acetamides, and LY315920 (6m) was selected for evaluation clinically as an hnps-PLA2 inhibitor.
