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172733-78-7

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172733-78-7 Usage

General Description

4-(acetylamino)-1-benzyl-4-phenylpiperidine is a chemical compound with a complex molecular structure. It contains an acetylamino group, a benzyl group, and a phenyl group attached to a piperidine ring. 4-(ACETYLAMINO)-1-BENZYL-4-PHENYLPIPERIDINE is commonly used as a precursor in the synthesis of various pharmaceutical drugs, including analgesics and anesthetics. It has also been studied for its potential in treating substance abuse disorders and neurological conditions. The unique structure of 4-(acetylamino)-1-benzyl-4-phenylpiperidine makes it a versatile building block in organic chemistry, allowing for the creation of diverse molecules with different biological activities.

Check Digit Verification of cas no

The CAS Registry Mumber 172733-78-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,7,2,7,3 and 3 respectively; the second part has 2 digits, 7 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 172733-78:
(8*1)+(7*7)+(6*2)+(5*7)+(4*3)+(3*3)+(2*7)+(1*8)=147
147 % 10 = 7
So 172733-78-7 is a valid CAS Registry Number.
InChI:InChI=1/C20H24N2O/c1-17(23)21-20(19-10-6-3-7-11-19)12-14-22(15-13-20)16-18-8-4-2-5-9-18/h2-11H,12-16H2,1H3,(H,21,23)

172733-78-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name N-(1-benzyl-4-phenylpiperidin-4-yl)acetamide

1.2 Other means of identification

Product number -
Other names 4-Acetamido-1-benzyl-4-phenylpiperidine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:172733-78-7 SDS

172733-78-7Relevant articles and documents

Structure-guided design and synthesis of P1′ position 1-phenylcycloalkylamine-derived pentapeptidic BACE1 inhibitors

Tagad, Harichandra D.,Hamada, Yoshio,Nguyen, Jeffrey-Tri,Hidaka, Koushi,Hamada, Takashi,Sohma, Youhei,Kimura, Tooru,Kiso, Yoshiaki

experimental part, p. 5238 - 5246 (2011/10/08)

Previously, we reported potent pentapeptidic BACE1 inhibitors with the hydroxymethylcarbonyl isostere as a substrate transition-state mimic. To improve the in vitro potency, we further reported pentapeptidic inhibitors with carboxylic acid bioisosteres at the P4 and P1′ positions. In the current study, we screened new P1′ position 1-phenylcycloalkylamine analogs to find non-acidic inhibitors that possess double-digit nanomolar range IC50 values. An extensive structure-activity relationship study was performed with various amine derivatives at the P1′ position. The most potent inhibitor of this pentapeptide series, KMI-1830, possessing 1-phenylcyclopentylamine at the P 1′ position had an IC50 value of 11.6 nM against BACE1 in vitro enzymatic assay.

A strategy for isotope containment during radiosynthesis - Devolatilisation of bromobenzene by fluorous-tagging-Ir-catalysed borylation en route to the 4-phenylpiperidine pharmacophore

Spivey, Alan C.,Martin, Laetitia J.,Tseng, Chih-Chung,Ellames, George J.,Kohler, Andrew D.

supporting information; experimental part, p. 4093 - 4095 (2009/02/07)

Syntheses of two 4-phenylpiperidines from bromobenzene have been developed involving anchoring to a fluorous-tag, Ir-catalysed borylation, Pd- and Co-catalysed elaboration then traceless cleavage. Although performed using 'cold' (i.e. unlabelled) bromoben

A reliable and efficient synthesis of SR 142801

Giardina,Grugni, Mario,Rigolio, Roberto,Vassallo, Marco,Erhard, Karl,Farina, Carlo

, p. 2307 - 2310 (2007/10/03)

A convenient synthesis of the potent human NK-3 receptor antagonist SR 142801, (S)-(+)-N-{{3-[1-benzoyl-3-(3,4-dichlorophenyl)piperidin-3-yl]prop-1 -yl}-4-phenylpiperidin-4-yl}-N-methylacetamide [(S)-(+)-(15)], is described. Improvements over the previously reported procedure are the preparation of the intermediate 5 via the novel imide 3 and subsequent reaction with the nucleophile 14, which reacts, regioselectively, at the endocyclic nitrogen.

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