172734-62-2

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 182621-51-8 (+)-3-(3,4-dichlorophenyl)-3-(3-hydroxypropyl)-piperidine 

Downstream Products

• 172734-63-3 N-tert-butoxycarbonyl-3-(3,4-dichlorophenyl)-3-(3-methanesulfonyloxypropyl)piperidine 
• 256497-28-6 N-tert-butoxycarbonyl-3-(3,4-dichlorophenyl)-3-[3-(1-phenyl-1,3,8-triazaspiro[4.5]decan-4-on-8-yl)propyl]piperidine 
• 256497-29-7 N-tert-butoxycarbonyl-3-(3,4-dichlorophenyl)-3-{3-[4-(pyrrolidinocarbonylmethyl)piperazin-1-yl]propyl}piperidine 
• 256497-24-2 N-tert-butoxycarbonyl-3-(3,4-dichlorophenyl)-3-[3-(4-phenylpiperazin-1-yl)propyl]piperidine 
• 256497-23-1 N-tert-butoxycarbonyl-3-(3,4-dichlorophenyl)-3-[3-(4-phenylpiperidin-1-yl)propyl]piperidine 
• 256497-27-5 N-tert-butoxycarbonyl-3-(3,4-dichlorophenyl)-3-[3-(1,2,3,4-tetrahydroisoquinolin-2-yl)propyl]piperidine 
• 256497-25-3 N-tert-butoxycarbonyl-3-(3,4-dichlorophenyl)-3-[3-(4-isopropylpiperazin-1-yl)propyl]piperidine 
• 256497-26-4 N-tert-butoxycarbonyl-3-(3,4-dichlorophenyl)-3-[3-(morpholin-4-yl)propyl]piperidine 
• 256497-22-0 N-tert-butoxycarbonyl-3-(3,4-dichlorophenyl)-3-(3-iodopropyl)piperidine 

Relevant academic research and scientific papers

Investigation of SAR requirements of SR 142801 through an indexed combinatorial library in solution

To rapidly gain information on structure-activity relationship (SAR) requirements of the human neurokinin 3 (hNK-3) receptor antagonist SR 142801, an indexed combinatorial library was synthesised in solution and screened on the hNK-3 receptor. SAR considerations drawn from binding affinity of combinatorial mixtures were confirmed through the synthesis and biological evaluation of some individual compounds.

COMPOUNDS WHICH ARE SELECTIVE ANTAGONISTS OF THE HUMAN NK3 RECEPTOR AND THEIR USE AS MEDICINAL PRODUCTS AND DIAGNOSTIC TOOLS

A compound of formula: STR1 in which: Ar represents a pyrid-2-yl or a phenyl which is unsubstituted or substituted by a halogen, a methyl or a (C 1-C 4)alkoxy;R 1 represents a methyl group;R 11 represents hydrogen; or R 1 and R 11 toge